Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria.

5-nitrofurancarboxaldehyde ESKAPE pathogens Groebke–Blackburn–Bienaymé multicomponent reaction antibacterial testing antimycobacterial activity flexible docking imidazo-fused azines and azoles strained ligand-protein interactions

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
06 Sep 2022
Historique:
received: 05 08 2022
revised: 26 08 2022
accepted: 31 08 2022
entrez: 23 9 2022
pubmed: 24 9 2022
medline: 24 9 2022
Statut: epublish

Résumé

A chemically diverse set of 13 5-nitrofuran-tagged heterocyclic compounds has been prepared via the Groebke-Blackburn-Bienaymé multicomponent reaction. The testing of these compounds against the so-called ESKAPE panel of pathogens identified an apparent lead compound-

Identifiants

pubmed: 36140307
pii: biomedicines10092203
doi: 10.3390/biomedicines10092203
pmc: PMC9496245
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Russian Foundation for Basic Research
ID : 20-53-56002
Organisme : Iranian National Science Foundation
ID : 98029575

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Auteurs

Alexander Sapegin (A)

Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.

Elizaveta Rogacheva (E)

Pasteur Institute of Epidemiology and Microbiology, 14 Mira Street, Saint Petersburg 197101, Russia.

Lyudmila Kraeva (L)

Pasteur Institute of Epidemiology and Microbiology, 14 Mira Street, Saint Petersburg 197101, Russia.

Maxim Gureev (M)

Laboratory of Chemoinformatics and Bioinformatics, Sechenov First Moscow State Medical University, Moscow 119435, Russia.

Marine Dogonadze (M)

Saint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.

Tatiana Vinogradova (T)

Saint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.

Petr Yablonsky (P)

Saint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, Saint Petersburg 191036, Russia.

Saeed Balalaie (S)

Peptide Chemistry Research Center, K. N. Toosi University of Technology, Tehran 19697, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences Kermanshah, Kermanshah 67155, Iran.

Sergey V Baykov (SV)

Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.

Mikhail Krasavin (M)

Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.
School for Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad 236041, Russia.

Classifications MeSH