Small Molecules as Toll-like Receptor 4 Modulators Drug and
docking
drug repurposing
innate immunity
toll-like receptor 4
virtual screening
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Sep 2022
19 Sep 2022
Historique:
received:
22
07
2022
revised:
08
09
2022
accepted:
09
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
The innate immunity toll-like receptor 4 (TLR4) system is a receptor of paramount importance as a therapeutic target. Virtual screening following a "computer-aided drug repurposing" approach was applied to the discovery of novel TLR4 modulators with a non-lipopolysaccharide-like structure. We screened almost 29,000 approved drugs and drug-like molecules from commercial, public, and
Identifiants
pubmed: 36140427
pii: biomedicines10092326
doi: 10.3390/biomedicines10092326
pmc: PMC9496124
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Economy, Industry and Competitiveness
ID : CTQ2014-57141-R
Organisme : Ministry of Economy, Industry and Competitiveness
ID : CTQ2017-88353-R
Organisme : Ministry of Economy, Industry and Competitiveness
ID : BES-2012-053653
Organisme : Ministry of Economy, Industry and Competitiveness
ID : BES-2015-071588
Organisme : Ministry of Economy, Industry and Competitiveness
ID : SAF2016-75988-R
Organisme : Ministry of Economy, Industry and Competitiveness
ID : PID2020-113588RB-I00
Organisme : Comunidad de Madrid
ID : S-2010/BMD-2332
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