Primary Bone Tumors of the Spine-Proposal for Treatment Based on a Single Centre Experience.

outcomes primary bone tumor treatment strategy

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
19 Sep 2022
Historique:
received: 27 07 2022
revised: 13 09 2022
accepted: 15 09 2022
entrez: 23 9 2022
pubmed: 24 9 2022
medline: 24 9 2022
Statut: epublish

Résumé

This study reports a large single-center series of primary bone tumors of the spine (PBTs). We aimed to review the concepts for management, as this kind of tumor represents a very rare entity, and also propose a new treatment algorithm. Retrospective analysis revealed 92 patients receiving surgery for PBTs from 2007 to 2019 at our center. They were analyzed based on surgical management and the course of the disease. A total of 145 surgical procedures were performed (50 cervical, 46 thoracic, 28 lumbar, and 21 sacral). Complete tumor resection was achieved in 65%, of which 22% showed tumor recurrence during follow-up (mean time to recurrence 334 days). The five-year mortality rate was significantly lower after complete resection (3% versus 25% after subtotal resection). Most of the patients improved in their symptoms through surgery. Regarding the tumor entity, the most common PBTs were vertebral hemangiomas (20%), osteoid osteomas (15%), and chordomas (16%). The Enneking graduation system showed a good correlation with the risk of recurrence and mortality. Complete resection in PBTs increased survival rates and remains the method of choice. Thus, quality of life-especially with a higher extent of resection-should be considered.

Identifiants

pubmed: 36140664
pii: diagnostics12092264
doi: 10.3390/diagnostics12092264
pmc: PMC9498005
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

J Neurosurg Spine. 2016 Jul;25(1):59-68
pubmed: 26943248
Spine (Phila Pa 1976). 2010 Oct 15;35(22):E1221-9
pubmed: 20562730
J Neurosurg Spine. 2016 Apr;24(4):644-51
pubmed: 26682601
Radiologia. 2016 Apr;58 Suppl 1:68-80
pubmed: 26917429
Eur Spine J. 2010 Feb;19(2):215-22
pubmed: 20039084
Medicine (Baltimore). 2018 Sep;97(37):e12366
pubmed: 30212997
World Neurosurg. 2017 Feb;98:329-333
pubmed: 27867127
JAMA. 2013 Nov 27;310(20):2191-4
pubmed: 24141714
Spine (Phila Pa 1976). 1997 May 1;22(9):1036-44
pubmed: 9152458
Eur Spine J. 2015 Aug;24(8):1747-53
pubmed: 25631339
Am Soc Clin Oncol Educ Book. 2015;:e656-60
pubmed: 25993237
Spine (Phila Pa 1976). 2011 May 1;36(10):830-6
pubmed: 20714276
Langenbecks Arch Chir Suppl Kongressbd. 1998;115:1324-7
pubmed: 9931871
Clin Orthop Relat Res. 2010 Jul;468(7):2000-2
pubmed: 20333492
Orthop Clin North Am. 2009 Jan;40(1):21-36, v
pubmed: 19064053
Global Spine J. 2019 May;9(1 Suppl):108S-116S
pubmed: 31157142
Clin Orthop Relat Res. 1980 Nov-Dec;(153):106-20
pubmed: 7449206
J Neurosurg Spine. 2011 Feb;14(2):143-50
pubmed: 21184634
Orthopedics. 2017 Jul 1;40(4):204-210
pubmed: 28732103
Neurosurgery. 2017 Mar 01;80(3S):S124-S130
pubmed: 28350941
Handb Clin Neurol. 2016;136:689-706
pubmed: 27430436
Spine J. 2019 Dec;19(12):1941-1949
pubmed: 31306757
Eur Spine J. 2013 Mar;22(3):593-601
pubmed: 23053752
Eur J Radiol. 2006 Apr;58(1):48-67
pubmed: 16431065
Medicine (Baltimore). 2018 Dec;97(52):e13730
pubmed: 30593146
Hum Pathol. 2017 May;63:89-97
pubmed: 28235628
Arch Orthop Trauma Surg. 2019 Oct;139(10):1339-1349
pubmed: 30877429
Ann Transl Med. 2019 May;7(10):226
pubmed: 31297391
Indian J Radiol Imaging. 2016 Apr-Jun;26(2):279-89
pubmed: 27413280
Spine J. 2016 Feb;16(2):259-69
pubmed: 26523962
J Neuroradiol. 2010 Mar;37(1):37-50
pubmed: 19781780

Auteurs

Nicole Lange (N)

Department of Neurosurgery, Klinikum Rechts der Isar, Technical University, 81675 Munich, Germany.

Ann-Kathrin Jörger (AK)

Department of Neurosurgery, Klinikum Rechts der Isar, Technical University, 81675 Munich, Germany.

Yu-Mi Ryang (YM)

Department of Neurosurgery, Helios Klinikum Berlin-Buch, 13125 Berlin, Germany.

Friederike Liesche-Starnecker (F)

Department of Neuropathology, Institute of Pathology, Technical University, 81675 Munich, Germany.

Jens Gempt (J)

Department of Neurosurgery, Klinikum Rechts der Isar, Technical University, 81675 Munich, Germany.

Bernhard Meyer (B)

Department of Neurosurgery, Klinikum Rechts der Isar, Technical University, 81675 Munich, Germany.

Classifications MeSH