Alteration of E2F2 Expression in Governing Endothelial Cell Senescence.
E2F2
cell cycle
endothelial cell
proliferation
senescence
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
24 08 2022
24 08 2022
Historique:
received:
23
07
2022
revised:
16
08
2022
accepted:
23
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Endothelial cell senescence has a vital implication for vascular dysfunction, leading to age-related cardiovascular disease, especially hypertension and atherosclerosis. E2F transcription factor 2 (E2F2) plays a critical role in cell proliferation, differentiation, and DNA damage response. Up to date, no study has ever connected E2F2 to vascular endothelial cell senescence. Here, we demonstrate that E2F2 is involved in endothelial cellular senescence. We found that E2F2 expression is decreased during the replicative senescence of human umbilical vein endothelial cells (HUVECs) and the aortas of aged mice. The knockdown of
Identifiants
pubmed: 36140689
pii: genes13091522
doi: 10.3390/genes13091522
pmc: PMC9498592
pii:
doi:
Substances chimiques
E2F2 Transcription Factor
0
E2F2 protein, human
0
Interleukin-6
0
Interleukin-8
0
Nitric Oxide Synthase Type III
EC 1.14.13.39
beta-Galactosidase
EC 3.2.1.23
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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