Reactive Nitrogen Species and Male Reproduction: Physiological and Pathological Aspects.
male infertility
oxidative stress
reactive nitrogen species
reactive oxygen species
sperm DNA fragmentation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Sep 2022
12 Sep 2022
Historique:
received:
23
06
2022
revised:
29
08
2022
accepted:
31
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Reactive nitrogen species (RNS), like reactive oxygen species (ROS), are useful for sustaining reproductive processes such as cell signaling, the regulation of hormonal biosynthesis, sperm capacitation, hyperactivation, and acrosome reaction. However, endogenous levels of RNS beyond physiological limits can impair fertility by disrupting testicular functions, reducing gonadotropin production, and compromising semen quality. Excessive RNS levels cause a variety of abnormalities in germ cells and gametes, particularly in the membranes and deoxyribonucleic acid (DNA), and severely impair the maturation and fertilization processes. Cell fragmentation and developmental blockage, usually at the two-cell stage, are also connected with imbalanced redox status of the embryo during its early developmental stage. Since high RNS levels are closely linked to male infertility and conventional semen analyses are not reliable predictors of the assisted reproductive technology (ART) outcomes for such infertility cases, it is critical to develop novel ways of assessing and treating oxidative and/or nitrosative stress-mediated male infertility. This review aims to explicate the physiological and pathological roles of RNS and their relationship with male reproduction.
Identifiants
pubmed: 36142487
pii: ijms231810574
doi: 10.3390/ijms231810574
pmc: PMC9506194
pii:
doi:
Substances chimiques
Reactive Nitrogen Species
0
Reactive Oxygen Species
0
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Int J Mol Sci. 2021 Sep 17;22(18):
pubmed: 34576205
Adv Exp Med Biol. 2008;636:172-85
pubmed: 19856168
Oxid Med Cell Longev. 2012;2012:973927
pubmed: 22900129
FEBS Lett. 1995 May 15;364(3):314-8
pubmed: 7758588
Oxid Med Cell Longev. 2014;2014:306179
pubmed: 25374651
Nat Rev Urol. 2010 Mar;7(3):153-61
pubmed: 20157305
J Surg Res. 1972 Sep;13(3):138-52
pubmed: 4343247
Nitric Oxide. 2009 Sep;21(2):92-103
pubmed: 19602444
Biol Reprod. 1995 Jan;52(1):1-7
pubmed: 7536043
Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):789-93
pubmed: 18455501
Fertil Steril. 2000 Aug;74(2):239-44
pubmed: 10927038
Asian J Androl. 2019 Nov-Dec;21(6):565-569
pubmed: 31006711
Am J Physiol. 1995 May;268(5 Pt 1):L699-722
pubmed: 7762673
Urology. 2009 Feb;73(2):225-31
pubmed: 19036419
Front Biosci. 2000 Jan 01;5:E1-E15
pubmed: 10702376
Antioxid Redox Signal. 2013 Jan 10;18(2):170-8
pubmed: 22563824
J Androl. 1998 Jan-Feb;19(1):58-64
pubmed: 9537292
Int Urol Nephrol. 2004;36(1):67-72
pubmed: 15338679
J Androl. 2001 Jul-Aug;22(4):568-74
pubmed: 11451353
Methods Mol Biol. 2013;927:351-61
pubmed: 22992927
Urology. 1996 Dec;48(6):835-50
pubmed: 8973665
Reprod Biomed Online. 2017 Jan;34(1):48-57
pubmed: 27839743
Reprod Biomed Online. 2004 Oct;9(4):466-8
pubmed: 15511350
Anim Reprod Sci. 2009 Jan;110(1-2):96-107
pubmed: 18262738
BJU Int. 2007 May;99(5):1086-90
pubmed: 17346270
BJU Int. 2005 Mar;95(4):503-7
pubmed: 15705068
Br J Cancer. 1990 Mar;61(3):354-61
pubmed: 2183871
J Assist Reprod Genet. 2016 May;33(5):627-635
pubmed: 26941096
Biol Reprod. 2004 Feb;70(2):267-76
pubmed: 14522829
Am J Reprod Immunol. 1992 Jan-Mar;27(1-2):89-92
pubmed: 1610494
J Assist Reprod Genet. 2015 May;32(5):757-64
pubmed: 25749739
Proc Natl Acad Sci U S A. 1990 Feb;87(4):1620-4
pubmed: 2154753
Andrologia. 1997 Sep-Oct;29(5):269-75
pubmed: 9350327
Fertil Steril. 2004 Apr;81(4):965-72
pubmed: 15066449
Nat Rev Urol. 2017 Aug;14(8):470-485
pubmed: 28508879
Fertil Steril. 1998 Dec;70(6):1143-7
pubmed: 9848308
J Cell Sci. 2013 Mar 15;126(Pt 6):1488-97
pubmed: 23378024
Biol Reprod. 1999 Sep;61(3):575-81
pubmed: 10456831
Redox Biol. 2013 Feb 08;1:226-33
pubmed: 24024156
Free Radic Res Commun. 1993;19(1):51-7
pubmed: 8225034
Fertil Steril. 2011 Jan;95(1):135-40
pubmed: 20684956
Int J Androl. 2012 Oct;35(5):741-51
pubmed: 22420564
J Pharm Biomed Anal. 2007 Jan 17;43(2):619-24
pubmed: 16949242
Reproduction. 2015 Jan;149(1):113-23
pubmed: 25385721
Arch Androl. 1990;25(3):277-93
pubmed: 2285351
Arch Androl. 2005 Mar-Apr;51(2):149-58
pubmed: 15804870
Mol Aspects Med. 2003 Aug-Oct;24(4-5):281-91
pubmed: 12893006
FASEB J. 1993 Feb 1;7(2):349-60
pubmed: 8440411
Am J Physiol. 1994 Nov;267(5 Pt 1):C1405-13
pubmed: 7977701
Int J Mol Sci. 2021 Apr 28;22(9):
pubmed: 33924958
J Androl. 2001 Jul-Aug;22(4):575-83
pubmed: 11451354
Fertil Steril. 2009 Aug;92(2):819-27
pubmed: 18710706
Hum Reprod Update. 1996 May-Jun;2(3):246-56
pubmed: 9079417
Free Radic Res. 1996 Oct;25(4):347-54
pubmed: 8889498
BJU Int. 2001 Dec;88(9):967-73
pubmed: 11851622
J Clin Endocrinol Metab. 2006 May;91(5):1968-75
pubmed: 16507629
Indian J Med Res. 2009 Apr;129(4):357-67
pubmed: 19535829
Free Radic Biol Med. 1987;3(4):259-303
pubmed: 2826304
Hum Reprod. 2007 Jul;22(7):1871-7
pubmed: 17478459
Curr Pharm Des. 2003;9(5):419-25
pubmed: 12570819
Andrologia. 2008 Apr;40(2):84-91
pubmed: 18336456
Int J Androl. 2009 Feb;32(1):46-56
pubmed: 19076252
Mol Hum Reprod. 2001 Oct;7(10):913-21
pubmed: 11574660
Biochem Biophys Res Commun. 1993 Jun 30;193(3):1347-54
pubmed: 8323555
Fertil Steril. 1986 Dec;46(6):1118-23
pubmed: 2946611
Redox Biol. 2013 Jan 21;1:145-52
pubmed: 24024147
Endocrinol Metab Clin North Am. 1998 Dec;27(4):831-50
pubmed: 9922910
Am J Clin Nutr. 1993 May;57(5 Suppl):715S-724S; discussion 724S-725S
pubmed: 8475889
Urologiia. 2005 Nov-Dec;(6):31-6
pubmed: 16419478
Urology. 1995 Jan;45(1):103-7
pubmed: 7817460
Curr Med Chem. 2001 Jun;8(7):851-62
pubmed: 11375755
Indian J Exp Biol. 2010 May;48(5):425-35
pubmed: 20795359
Am J Reprod Immunol. 1996 Oct;36(4):193-7
pubmed: 8911625
FEBS J. 2006 Jun;273(11):2329-44
pubmed: 16704409
Fertil Steril. 2006 Apr;85(4):947-53
pubmed: 16580379
Fertil Steril. 2007 May;87(5):1059-63
pubmed: 17280661
BMC Clin Pathol. 2007 Jun 01;7:6
pubmed: 17540046
J Anim Sci. 2006 Aug;84(8):2089-100
pubmed: 16864869
Iran Biomed J. 2007 Oct;11(4):259-64
pubmed: 18392088
Reprod Biol. 2019 Dec;19(4):329-339
pubmed: 31757605
J Biol Chem. 2001 Aug 3;276(31):28799-805
pubmed: 11373284
Indian J Exp Biol. 2005 Nov;43(11):963-74
pubmed: 16315393
Endocrinology. 2003 Jul;144(7):3092-100
pubmed: 12810565
J Androl. 2004 Jul-Aug;25(4):455-65
pubmed: 15223833
Free Radic Biol Med. 1995 Mar;18(3):487-95
pubmed: 9101239
Hum Reprod Update. 1998 Jan-Feb;4(1):3-24
pubmed: 9622410
Reprod Biol Endocrinol. 2005 Nov 29;3:67
pubmed: 16313680
Hum Reprod. 2001 Sep;16(9):1922-30
pubmed: 11527899
Biol Reprod. 1997 May;56(5):1216-20
pubmed: 9160721
J Androl. 1992 Nov-Dec;13(6):551-9
pubmed: 1338069
Mol Hum Reprod. 1997 Sep;3(9):755-62
pubmed: 9358000
J Cell Physiol. 1992 Jun;151(3):466-77
pubmed: 1338331
Nat Med. 2013 Jan;19(1):101-6
pubmed: 23202294
Biol Reprod. 2015 Nov;93(5):119
pubmed: 26447142
Biofactors. 2020 Mar;46(2):206-219
pubmed: 31185138
Methods Enzymol. 2002;348:93-112
pubmed: 11885298
Biochem Biophys Res Commun. 2007 Sep 21;361(2):561-5
pubmed: 17662690
Hum Reprod. 1995 Jul;10(7):1786-90
pubmed: 8582980
J Urol. 1996 Dec;156(6):1952-8
pubmed: 8911364
Physiol Rev. 2007 Jan;87(1):315-424
pubmed: 17237348
J Assist Reprod Genet. 2015 Dec;32(12):1721-9
pubmed: 26431955
Free Radic Biol Med. 2009 May 15;46(10):1420-7
pubmed: 19268528
Int J Androl. 1993 Feb;16(1):21-5
pubmed: 8385650
Fertil Steril. 2016 Sep 1;106(3):566-573.e10
pubmed: 27260688
Front Biosci (Schol Ed). 2017 Jun 1;9(3):420-447
pubmed: 28410127
Arch Iran Med. 2014 Oct;17(10):713-21
pubmed: 25305772
Maturitas. 2010 May;66(1):16-22
pubmed: 20153946
Chem Res Toxicol. 1992 Nov-Dec;5(6):834-42
pubmed: 1336991
Med Sci Monit. 2006 Mar;12(3):CR103-6
pubmed: 16501419
J Androl. 2004 Mar-Apr;25(2):245-9
pubmed: 14760010
Fertil Steril. 2014 Jul;102(1):151-159.e5
pubmed: 24825428