Plasma Small Extracellular Vesicle Cathepsin D Dysregulation in
C9orf72
GRN
cathepsin D
endo-lysosomal pathway
extracellular vesicles
frontotemporal dementia
frontotemporal lobar degeneration
lysosomal protease
plasma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2022
14 Sep 2022
Historique:
received:
19
08
2022
revised:
08
09
2022
accepted:
11
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Emerging data suggest the roles of endo-lysosomal dysfunctions in frontotemporal lobar degeneration (FTLD) and in other dementias. Cathepsin D is one of the major lysosomal proteases, mediating the degradation of unfolded protein aggregates. In this retrospective study, we investigated cathepsin D levels in human plasma and in the plasma small extracellular vesicles (sEVs) of 161 subjects (40 sporadic FTLD, 33 intermediate/pathological
Identifiants
pubmed: 36142612
pii: ijms231810693
doi: 10.3390/ijms231810693
pmc: PMC9504770
pii:
doi:
Substances chimiques
C9orf72 Protein
0
C9orf72 protein, human
0
GRN protein, human
0
Progranulins
0
Protein Aggregates
0
Cathepsin D
EC 3.4.23.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero della Salute
ID : RF-2016-02361492
Organisme : Ministero della Salute
ID : Ricerca Corrente
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