Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre.
H3F3A
bone sarcoma
denosumab
diagnosis
giant cell tumour of bone
malignant transformation
radiological features
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2022
14 Sep 2022
Historique:
received:
03
08
2022
revised:
29
08
2022
accepted:
04
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Giant cell tumour of bone (GCTB) is a benign, locally aggressive primary bone neoplasm that represents 5% of all bone tumours. The principal treatment approach is surgery. Although generally GCTB is considered only a locally aggressive disease, it can metastasise, and lung metastases occur in 1-9% of patients. To date, only the use of denosumab has been approved as medical treatment for GCTB. Even more rarely, GCTB undergoes sarcomatous transformation into a malignant tumour (4% of all GCTB), but history of this malignant transformation is unclear and unpredictable. Considering the rarity of the event, the data in the literature are few. In this review, we summarise published data of GCTB malignant transformation and we analyse three cases of malignant transformation of GCTB, evaluating histopathology, genetics, and radiological aspects. Despite the rarity of this event, we conclude that a strict follow up is recommended to detect early malignant transformation.
Identifiants
pubmed: 36142631
pii: ijms231810721
doi: 10.3390/ijms231810721
pmc: PMC9506170
pii:
doi:
Substances chimiques
Denosumab
4EQZ6YO2HI
Types de publication
Case Reports
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Jpn J Clin Oncol. 2018 Jul 01;48(7):640-652
pubmed: 29741702
Bone Joint J. 2021 Jan;103-B(1):184-191
pubmed: 33380180
Front Oncol. 2020 Oct 02;10:580605
pubmed: 33123484
Cancer. 2022 May 15;128(10):1958-1966
pubmed: 35201621
Lancet Oncol. 2013 Aug;14(9):901-8
pubmed: 23867211
Lancet. 2012 May 19;379(9829):1879-86
pubmed: 22595799
Arch Pathol Lab Med. 1989 Apr;113(4):416-9
pubmed: 2468324
Eur J Cancer. 2016 May;59:1-12
pubmed: 26990281
Ann Oncol. 2015 Oct;26(10):2149-54
pubmed: 26205395
Int J Radiat Oncol Biol Phys. 2010 Oct 1;78(2):494-8
pubmed: 20004531
J Bone Joint Surg Am. 1999 Nov;81(11):1566-73
pubmed: 10565648
Oncol Rep. 2007 Dec;18(6):1365-71
pubmed: 17982618
Int Orthop. 2006 Dec;30(6):499-504
pubmed: 16909252
Hum Pathol. 2018 Mar;73:41-50
pubmed: 29241742
Oncotarget. 2015 Jun 10;6(16):13946-61
pubmed: 26062442
Nature. 1999 Jan 28;397(6717):315-23
pubmed: 9950424
Technol Cancer Res Treat. 2019 Jan 1;18:1533033819840000
pubmed: 30935298
Cancer. 2003 May 15;97(10):2520-9
pubmed: 12733152
Genes Chromosomes Cancer. 2017 Oct;56(10):711-718
pubmed: 28545165
Case Rep Pathol. 2015;2015:897230
pubmed: 25722909
Cancer. 2008 Jul 15;113(2):419-25
pubmed: 18484657
J Bone Joint Surg Br. 2012 Mar;94(3):419-24
pubmed: 22371553
Int J Radiat Oncol Biol Phys. 1995 Oct 15;33(3):689-94
pubmed: 7558960
J Clin Oncol. 2012 Jun 10;30(17):2112-8
pubmed: 22564997
BMC Cancer. 2021 Jan 22;21(1):89
pubmed: 33482769
Cells. 2020 Oct 31;9(11):
pubmed: 33142760
Cancer. 1962 Jul-Aug;15:653-90
pubmed: 14450279
J Cancer Res Clin Oncol. 2004 Jun;130(6):357-61
pubmed: 15042358
Sarcoma. 2010;2010:
pubmed: 20706639
Skeletal Radiol. 2020 Sep;49(9):1345-1358
pubmed: 32335707
Nature. 2012 May 3;485(7396):69-74
pubmed: 22522930
Am J Surg Pathol. 2020 Jan;44(1):1-10
pubmed: 31651524
Hum Pathol. 2017 May;63:89-97
pubmed: 28235628
Ann Surg Oncol. 2015 Sep;22(9):2860-8
pubmed: 26033180
J Bone Joint Surg Am. 1987 Jan;69(1):106-14
pubmed: 3805057
J Bone Joint Surg Br. 1998 Jan;80(1):43-7
pubmed: 9460951
J Bone Joint Surg Am. 2008 May;90(5):1060-7
pubmed: 18451399
Osteoporos Int. 2011 Feb;22(2):435-46
pubmed: 20571772
Ann Surg Oncol. 2010 Mar;17(3):694-701
pubmed: 19902306
Clin Orthop Relat Res. 2018 Sep;476(9):1773-1782
pubmed: 30794215
J Bone Joint Surg Am. 1986 Sep;68(7):1073-9
pubmed: 3745247
Jpn J Clin Oncol. 2017 Nov 1;47(11):1090-1096
pubmed: 29048579
Mod Pathol. 2019 Dec;32(12):1751-1761
pubmed: 31285528
J Orthop Surg Res. 2020 Nov 7;15(1):510
pubmed: 33160367
AJR Am J Roentgenol. 1992 Feb;158(2):331-4
pubmed: 1729794
Lancet Oncol. 2019 Dec;20(12):1719-1729
pubmed: 31704134
Transl Oncol. 2020 Feb;13(2):295-299
pubmed: 31875575
EBioMedicine. 2017 Aug;22:2-9
pubmed: 28596133
J Orthop Sci. 2022 Jan;27(1):215-221
pubmed: 33358447
World J Surg Oncol. 2018 Sep 19;16(1):191
pubmed: 30231890
J Bone Oncol. 2020 Nov 05;26:100334
pubmed: 33251099
EFORT Open Rev. 2021 Aug 10;6(8):641-650
pubmed: 34532071
J Surg Oncol. 2017 Dec;116(7):907-913
pubmed: 28650536
Tumori. 2018 Jan-Feb;104(1):30-36
pubmed: 29218692
Nature. 1996 Oct 10;383(6600):525-8
pubmed: 8849723
Clin Transl Oncol. 2015 Jun;17(6):419-30
pubmed: 25617146
Virchows Arch. 2012 Mar;460(3):327-34
pubmed: 22350004
Lancet Oncol. 2010 Sep;11(9):815
pubmed: 20816372
N Engl J Med. 2009 Aug 20;361(8):745-55
pubmed: 19671656