Manganese-Induced Toxicity in

Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Manganese / toxicity Manganese Poisoning Nucleotides Transcriptome
Caenorhabditis elegans manganese metal response oxidative stress stress response transcriptome analysis

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
15 Sep 2022
Historique:
received: 01 08 2022
revised: 09 09 2022
accepted: 13 09 2022
entrez: 23 9 2022
pubmed: 24 9 2022
medline: 28 9 2022
Statut: epublish

Résumé

Manganese (Mn) is an essential ubiquitous transition metal and, when occupationally or environmentally overexposed, a well-known risk factor for several neurological pathologies. However, the molecular mechanisms underlying Mn-induced neurotoxicity are largely unknown. In this study, addressing RNA-Seq analysis, bioavailability and survival assays, key pathways of transcriptional responses to Mn overexposure were investigated in the model organism

Identifiants

DOI: 10.3390/ijms231810748 PMID: 36142660 PMC: PMC9502620
pubmed: 36142660
pii: ijms231810748
doi: 10.3390/ijms231810748
pmc: PMC9502620
pii:
doi:

Substances chimiques

Caenorhabditis elegans Proteins 0
Nucleotides 0
Manganese 42Z2K6ZL8P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : German National Academic Foundation
ID : Fellowship
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR 2558, BO4103/4-2

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Auteurs

Merle M Nicolai (MM)

Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, 14558 Nuthetal, Germany.

Marcello Pirritano (M)

Molecular Cell Biology and Microbiology, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.

Gilles Gasparoni (G)

Department for Genetics/Epigenetics, Centre for Human and Molecular Biology, Saarland University, Campus Geb. A2 4, 66123 Saarbrücken, Germany.
ORCID: 0000-0002-6423-4637

Michael Aschner (M)

Department of Molecular Pharmacology, Neuroscience, and Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
ORCID: 0000-0002-2619-1656

Martin Simon (M)

Molecular Cell Biology and Microbiology, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
ORCID: 0000-0002-0962-7788

Julia Bornhorst (J)

Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Gaußstraße 20, 42119 Wuppertal, Germany.
TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly (FOR 2558), Berlin-Potsdam-Jena-Wuppertal, 14558 Nuthetal, Germany.
ORCID: 0000-0002-4018-2406

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Manganese-Induced Toxicity in
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Manganese-Induced Toxicity in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'helminthes › Protéines de Caenorhabditis elegans › Manganese-Induced Toxicity in
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Manganèse › Manganese-Induced Toxicity in
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Empoisonnement aux métaux lourds › Intoxication au manganèse › Manganese-Induced Toxicity in
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Manganese-Induced Toxicity in
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Manganese-Induced Toxicity in