Flavones: Six Selected Flavones and Their Related Signaling Pathways That Induce Apoptosis in Cancer.
anticancer
apoptosis
cancer
cell signaling pathway
flavones
flavonoids
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Sep 2022
19 Sep 2022
Historique:
received:
31
08
2022
revised:
14
09
2022
accepted:
15
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Cancer is a horrific disease that, to date, has no cure. It is caused by various factors and takes many lives. Apoptosis is a programmed cell death mechanism and if it does not function correctly in cancer cells, it can lead to severe disease. There are various signaling pathways for regulating apoptosis in cancer cells. Flavonoids are non-artificial natural bioactive compounds that are gaining attention as being capable of for inducing apoptosis in cancer cells. Among these, in this study, we focus on flavones. Flavones are a subclass of the numerous available flavonoids and possess several bioactive functions. Some of the most reported and well-known critical flavones, namely apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin, are discussed in depth in this review. Our main aim is to investigate the effects of the selected flavones on apoptosis and cell signaling pathways that contribute to death due to various types of cancers.
Identifiants
pubmed: 36142874
pii: ijms231810965
doi: 10.3390/ijms231810965
pmc: PMC9505532
pii:
doi:
Substances chimiques
Flavones
0
Flavonoids
0
Apigenin
7V515PI7F6
Luteolin
KUX1ZNC9J2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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