Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia.
antipsychotics
biomarkers
malonylation
post-translational modifications
schizophrenia
shotgun proteomics
succinylation
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
30 Aug 2022
30 Aug 2022
Historique:
received:
05
07
2022
revised:
24
08
2022
accepted:
27
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Two protein post-translational modifications, lysine succinylation and malonylation, are implicated in protein regulation, glycolysis, and energy metabolism. The precursors of these modifications, succinyl-CoA and malonyl-CoA, are key players in central metabolic processes. Both modification profiles have been proven to be responsive to metabolic stimuli, such as hypoxia. As mitochondrial dysfunction and metabolic dysregulation are implicated in schizophrenia and other psychiatric illnesses, these modification profiles have the potential to reveal yet another layer of protein regulation and can furthermore represent targets for biomarkers that are indicative of disease as well as its progression and treatment. In this work, data from shotgun mass spectrometry-based quantitative proteomics were compiled and analyzed to probe the succinylome and malonylome of postmortem brain tissue from patients with schizophrenia against controls and the human oligodendrocyte precursor cell line MO3.13 with the dizocilpine chemical model for schizophrenia, three antipsychotics, and co-treatments. Several changes in the succinylome and malonylome were seen in these comparisons, revealing these modifications to be a largely under-studied yet important form of protein regulation with broad potential applications.
Identifiants
pubmed: 36143193
pii: jpm12091408
doi: 10.3390/jpm12091408
pmc: PMC9500613
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : São Paulo Research Foundation
ID : 2013/08711-3
Organisme : São Paulo Research Foundation
ID : 2014/10068-4
Organisme : São Paulo Research Foundation
ID : 2015/23049-0
Organisme : São Paulo Research Foundation
ID : 2016/07948-8
Organisme : São Paulo Research Foundation
ID : 2016/07332-7
Organisme : São Paulo Research Foundation
ID : 2017/18715-4
Organisme : São Paulo Research Foundation
ID : 2017/25055-3
Organisme : São Paulo Research Foundation
ID : 2017/25588-1
Organisme : São Paulo Research Foundation
ID : 2018/01410-1
Organisme : São Paulo Research Foundation
ID : 2018/14666-4
Organisme : São Paulo Research Foundation
ID : 2019/05747-3
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 88887.495565/2020-00
Organisme : National Council for Scientific and Technological Development
ID : 302453/2017-2
Références
Mol Psychiatry. 2008 Sep;13(9):878-96
pubmed: 18504422
Nat Neurosci. 2005 Aug;8(8):1043-50
pubmed: 16025109
J Amino Acids. 2011;2011:843206
pubmed: 22312474
Adv Exp Med Biol. 2017;974:269-277
pubmed: 28353246
Proteomics Clin Appl. 2007 Oct;1(10):1291-305
pubmed: 21136626
Cell Rep. 2018 Feb 6;22(6):1365-1373
pubmed: 29425493
J Clin Psychiatry. 2010 Apr;71(4):463-74
pubmed: 20156410
Neuropsychopharmacology. 2014 May;39(6):1347-54
pubmed: 24196945
Mol Psychiatry. 2015 May;20(5):563-572
pubmed: 25113377
J Neurosci. 2016 Nov 9;36(45):11411-11417
pubmed: 27911743
J Neurosci Res. 2017 Nov;95(11):2244-2252
pubmed: 28631845
Curr Diab Rep. 2010 Jun;10(3):209-16
pubmed: 20425584
Am J Psychiatry. 1997 May;154(5):682-4
pubmed: 9137127
Cell Chem Biol. 2017 Jun 22;24(6):673-684.e4
pubmed: 28479296
Electron Physician. 2017 Oct 25;9(10):5478-5486
pubmed: 29238487
Mol Cell Neurosci. 2016 Jun;73:84-95
pubmed: 26837043
Eur Neuropsychopharmacol. 2001 Oct;11 Suppl 4:S397-403
pubmed: 11587887
Int J Neuropsychopharmacol. 2014 Jan;17(1):149-55
pubmed: 24074141
Schizophr Res. 2016 Nov;177(1-3):70-77
pubmed: 27094720
Neuron. 1993 May;10(5):805-14
pubmed: 7684233
Behav Brain Res. 2009 Dec 7;204(2):410-5
pubmed: 19716985
Biol Psychiatry. 2010 Jul 1;68(1):70-7
pubmed: 20494336
Transl Psychiatry. 2017 Dec 11;7(12):1278
pubmed: 29225346
Early Interv Psychiatry. 2019 Oct;13(5):1021-1031
pubmed: 30277314
Mol Psychiatry. 2003 Feb;8(2):148-55
pubmed: 12610647
Brain Res. 1995 May 29;681(1-2):109-16
pubmed: 7552267
Science. 2011 Nov 11;334(6057):806-9
pubmed: 22076378
J Comput Chem. 2018 Aug 15;39(22):1757-1763
pubmed: 29761520
J Psychiatr Res. 2012 Oct;46(10):1359-65
pubmed: 22884423
Eur Arch Psychiatry Clin Neurosci. 2015 Oct;265(7):601-12
pubmed: 26232077
Am J Psychiatry. 2005 Sep;162(9):1733-5
pubmed: 16135634
Prog Neurobiol. 2011 Jan;93(1):13-24
pubmed: 20950668
Br J Psychiatry. 2010 Jun;196(6):434-9
pubmed: 20513851
J Neurosci. 1998 Apr 1;18(7):2423-36
pubmed: 9502803
Schizophr Res. 2012 Mar;135(1-3):181-6
pubmed: 22264600
Adv Pharmacol. 2016;76:351-82
pubmed: 27288082
BMC Bioinformatics. 2018 Jun 25;19(1):237
pubmed: 29940836
BMC Psychiatry. 2009 Apr 30;9:17
pubmed: 19405953
PLoS Med. 2005 May;2(5):e141
pubmed: 15916472
Nat Chem Biol. 2011 Jan;7(1):58-63
pubmed: 21151122
Biol Psychiatry. 2008 Jul 15;64(2):81-8
pubmed: 18395701
Neurochem Res. 2002 Oct;27(10):1193-200
pubmed: 12462417
Schizophr Res. 2013 May;146(1-3):162-9
pubmed: 23499243
Mol Psychiatry. 2008 Mar;13(3):245-60
pubmed: 17925796
Schizophr Res. 2007 Dec;97(1-3):254-63
pubmed: 17601703
J Psychiatr Res. 2010 Feb;44(3):149-56
pubmed: 19699489
Methods Mol Biol. 2019;1916:319-328
pubmed: 30535709
Lancet. 1978 Jul 29;2(8083):223-6
pubmed: 79025
PLoS One. 2018 Feb 12;13(2):e0191900
pubmed: 29432431
Arch Gen Psychiatry. 1998 Mar;55(3):235-43
pubmed: 9510217
Nucleic Acids Res. 2019 Jan 8;47(D1):D442-D450
pubmed: 30395289
Arch Gen Psychiatry. 1995 May;52(5):341-51
pubmed: 7726714
Arch Gen Psychiatry. 2000 Jun;57(6):553-9
pubmed: 10839333
Arch Gen Psychiatry. 1992 Dec;49(12):921-6
pubmed: 1449382
Exp Brain Res. 2006 Jul;172(4):556-60
pubmed: 16710682
Ther Adv Psychopharmacol. 2013 Feb;3(1):33-51
pubmed: 23983991
Br J Psychiatry Suppl. 2001 Apr;40:s18-24
pubmed: 11315219
J Psychiatr Res. 1999 Nov-Dec;33(6):523-33
pubmed: 10628529
Psychiatr Clin North Am. 2003 Mar;26(1):85-102
pubmed: 12683261
Compr Psychiatry. 1990 Jul-Aug;31(4):315-26
pubmed: 2201482
J Clin Med. 2020 Nov 26;9(12):
pubmed: 33255883
Acta Psychiatr Scand. 1987 Dec;76(6):628-41
pubmed: 3502060
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):225-33
pubmed: 16901598
Am J Psychiatry. 2000 Apr;157(4):514-20
pubmed: 10739409
Mol Psychiatry. 2003 Mar;8(3):261-74
pubmed: 12660799
Mol Cell. 2015 Jul 16;59(2):321-32
pubmed: 26073543
Cell Rep. 2013 Aug 29;4(4):842-51
pubmed: 23954790
Mol Cell Proteomics. 2015 Sep;14(9):2308-15
pubmed: 25717114
Schizophr Res. 2004 Apr 1;67(2-3):269-75
pubmed: 14984887
Nature. 2017 Dec 14;552(7684):273-277
pubmed: 29211711
Antioxid Redox Signal. 2011 Oct 1;15(7):2067-79
pubmed: 20673161
Psychiatry Res. 1988 Apr;24(1):1-11
pubmed: 2899331
J Psychiatr Res. 2009 Jul;43(11):978-86
pubmed: 19110265
Schizophr Bull. 2008 Jan;34(1):155-72
pubmed: 17562694
Biol Psychiatry. 2011 Jan 15;69(2):163-72
pubmed: 20887976
Compr Psychiatry. 1999 Nov-Dec;40(6):407-14
pubmed: 10579370
Front Behav Neurosci. 2013 Oct 16;7:140
pubmed: 24137114
Lancet. 2003 Sep 6;362(9386):798-805
pubmed: 13678875
Curr Opin Psychiatry. 2008 Mar;21(2):151-6
pubmed: 18332662
Schizophr Res. 2000 May 5;42(3):193-208
pubmed: 10785578
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
Curr Drug Targets CNS Neurol Disord. 2004 Dec;3(6):515-33
pubmed: 15581421
Cell Metab. 2013 Dec 3;18(6):920-33
pubmed: 24315375
Neurochem Int. 2006 May-Jun;48(6-7):541-6
pubmed: 16517016
Open Access J Transl Med Res. 2018;2(3):84-91
pubmed: 34079927
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):827-32
pubmed: 15916843
Acta Psychiatr Scand. 2006 Nov;114(5):346-51
pubmed: 17022794
Genes Dis. 2019 Oct 08;7(2):166-171
pubmed: 32215286
Lancet Psychiatry. 2020 Jan;7(1):64-77
pubmed: 31860457
Biol Psychiatry. 2006 Apr 15;59(8):721-9
pubmed: 16427029
Am J Psychiatry. 2000 Sep;157(9):1475-84
pubmed: 10964865
Psychiatry Res. 2016 Apr 30;238:60-67
pubmed: 27086212
J Proteome Res. 2016 Jun 3;15(6):2060-71
pubmed: 27183143
Brain. 2014 Jan;137(Pt 1):12-32
pubmed: 23869106
Schizophr Bull. 1995;21(2):241-50
pubmed: 7631171
J Neurocytol. 2003 Jan;32(1):25-38
pubmed: 14618099
Front Behav Neurosci. 2015 Apr 01;9:75
pubmed: 25883558
Am J Psychiatry. 1997 Dec;154(12):1663-9
pubmed: 9396943