Low Bone Turnover Due to Hypothyroidism or Anti-Resorptive Treatment Does Not Affect Whole-Body Glucose Homeostasis in Male Mice.
bisphosphonates
bone metabolism
glucose homeostasis
glucose uptake
hypothyroidism
thyroid hormones
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
06 Sep 2022
06 Sep 2022
Historique:
received:
08
08
2022
revised:
31
08
2022
accepted:
02
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Bone is a large and dynamic tissue and its maintenance requires high amounts of energy as old or damaged bone structures need to be replaced during the process of bone remodeling. Glucose homeostasis is an essential prerequisite for a healthy bone and vice versa, the skeleton can act as an endocrine organ on energy metabolism. We recently showed that hypothyroidism in mice leads to an almost complete arrest of bone remodeling. Here, we aimed to investigate whether the profound suppression of bone remodeling affects whole-body glucose homeostasis. To that end, male C57BL/6JRj mice were rendered hypothyroid over 4 weeks using methimazole and sodium perchlorate in the drinking water. We confirmed trabecular bone gain due to decreased bone turnover in hypothyroid mice with decreased cortical but increased vertebral bone strength. Further, we found impaired glucose handling but not insulin resistance with hypothyroidism. In hypothyroid bone, glucose uptake and expression of glucose transporter
Identifiants
pubmed: 36143246
pii: jpm12091462
doi: 10.3390/jpm12091462
pmc: PMC9502862
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fritz-Thyssen Foundation
ID : Az. 10.20.2.042MN
Organisme : Elsbeth Bonhoff Foundation
ID : Az.231
Organisme : MeDDrive Start grant of the Technische Universität Dresden
ID : 60483
Organisme : Deutsche Forschungsgemeinschaft
ID : LA 4945/1-1
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