Multi-Omic Admission-Based Prognostic Biomarkers Identified by Machine Learning Algorithms Predict Patient Recovery and 30-Day Survival in Trauma Patients.
biomarkers
machine learning
multi-omics
prognostic
proteomics
trauma
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
23 Aug 2022
23 Aug 2022
Historique:
received:
08
07
2022
revised:
03
08
2022
accepted:
18
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Admission-based circulating biomarkers for the prediction of outcomes in trauma patients could be useful for clinical decision support. It is unknown which molecular classes of biomolecules can contribute biomarkers to predictive modeling. Here, we analyzed a large multi-omic database of over 8500 markers (proteomics, metabolomics, and lipidomics) to identify prognostic biomarkers in the circulating compartment for adverse outcomes, including mortality and slow recovery, in severely injured trauma patients. Admission plasma samples from patients (
Identifiants
pubmed: 36144179
pii: metabo12090774
doi: 10.3390/metabo12090774
pmc: PMC9500723
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL098036
Pays : United States
Organisme : NHLBI NIH HHS
ID : R38 HL150207
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM127027
Pays : United States
Organisme : NIH HHS
ID : R35GM119526
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : DP2AI164325
Organisme : NIH HHS
ID : R35-GM-127027
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119526
Pays : United States
Organisme : NIAID NIH HHS
ID : DP2 AI164325
Pays : United States
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