Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E.
HCoV-229E
adsorption
cyclodextrin
epigallocatechin gallate
inactivation
influenza virus
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
06 Sep 2022
06 Sep 2022
Historique:
received:
27
08
2022
revised:
02
09
2022
accepted:
02
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
Natural products are attractive antiviral agents because they are environment-friendly and mostly harmless. Epigallocatechin gallate (EGCg), a type of catechin, is a well-known natural antiviral agent that can inhibit various viruses. However, EGCg easily oxidizes and loses its physiological activity. Although this problem can be overcome by combining EGCg with cyclodextrin (CD-EGCg), which makes it stable in water at high concentrations, the antiviral effect of this compound remains unclear. Here, we show that in Madin-Darby canine kidney (MDCK) and MRC-5 cells, CD-EGCg is cytotoxic for 50% of cells at 85.61 and 65.34 ppm, respectively. Furthermore, CD-EGCg mainly shows its antiviral effect during the adsorption step for all four influenza virus strains (median effect concentration (EC
Identifiants
pubmed: 36144398
pii: microorganisms10091796
doi: 10.3390/microorganisms10091796
pmc: PMC9503507
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Office for Novel Coronavirus Disease Control, Cabinet Secretariat, Government of Japan
ID : COVID-19 AI and Simulation Project
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