Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity.
antimicrobial agents
cytotoxicity
imidazo[2,1-b]thiazole
indole
isatin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Sep 2022
07 Sep 2022
Historique:
received:
25
07
2022
revised:
30
08
2022
accepted:
05
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis. The discovery of novel compounds active against human pathogenic bacteria and fungi is an urgent need, and the isatin may represent the suitable scaffold in the design of biologically relevant antimicrobials. A small library of 18 isatin hybrids was synthetized and evaluated for their antimicrobial potential on three reference strains:
Identifiants
pubmed: 36144518
pii: molecules27185781
doi: 10.3390/molecules27185781
pmc: PMC9505023
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Indoles
0
Isatin
82X95S7M06
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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