Dahl Salt-Resistant Rat Is Protected against Hypertension during Diet-Induced Obesity.
Dahl salt-resistant rat
Dahl salt-sensitive rat
hypertension
obesity
perivascular adipose tissue
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
16 Sep 2022
16 Sep 2022
Historique:
received:
12
08
2022
revised:
07
09
2022
accepted:
14
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
A high-fat diet (HFD) frequently causes obesity-induced hypertension. Because Dahl salt-resistant rats are protected against hypertension after high-salt or high-fructose intake, it is of interest whether this model also protects against hypertension after diet-induced obesity. We tested the hypothesis that Dahl salt-resistant rat protects against hypertension during diet-induced obesity. Dahl salt-sensitive (SS) and Dahl salt-resistant (SR) rats were fed a HFD (60% fat) or a chow diet (CD; 8% fat) for 12 weeks. We measured blood pressure using the tail-cuff method. The paraffin sections of thoracic perivascular adipose tissue (tPVAT) were stained with hematoxylin/eosin and trichrome. The expression of genes in the tPVAT and kidneys were measured by reverse transcription-quantitative polymerase chain reaction. The HFD induced hypertension in SS (p < 0.01) but not SR rats, although it increased body weight gain (p < 0.05) and tPVAT weight (p < 0.01) in both rats. The HFD did not affect the expression of genes related to any of the adipocyte markers in both rats, although SR rats had reduced beige adipocyte marker Tmem26 levels (p < 0.01) and increased anti-inflammatory cytokine adiponectin (p < 0.05) as compared with SS rat. The HFD did not affect the mRNA expression of contractile factors in the tPVAT of SS and SR rats. SR rats are protected against hypertension during diet-induced obesity. This result implies that the genetic trait determining salt sensitivity may also determine fructose and fat sensitivity and that it is associated with the prevention of hypertension.
Identifiants
pubmed: 36145220
pii: nu14183843
doi: 10.3390/nu14183843
pmc: PMC9506364
pii:
doi:
Substances chimiques
Adiponectin
0
Cytokines
0
RNA, Messenger
0
Sodium Chloride, Dietary
0
Fructose
30237-26-4
Sodium Chloride
451W47IQ8X
Paraffin
8002-74-2
Eosine Yellowish-(YS)
TDQ283MPCW
Hematoxylin
YKM8PY2Z55
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : NRF-2021R1A2B502001763
Organisme : National Research Foundation of Korea
ID : NRF-2021R1A4A1021617
Organisme : Korea Health Industry Development Institute
ID : HI15C0001
Pays : Republic of Korea
Organisme : National Research Foundation of Korea
ID : 2021K2A9A2A07000135
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