Albumin-Mediated Size Exclusion Chromatography: The Apparent Molecular Weight of PSMA Radioligands as Novel Parameter to Estimate Their Blood Clearance Kinetics.
PSMA
albumin
blood clearance
pharmacokinetics
plasma protein binding
prostate cancer
radioligand therapy
rhPSMA
size exclusion chromatography
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
19 Sep 2022
19 Sep 2022
Historique:
received:
11
08
2022
revised:
13
09
2022
accepted:
14
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
A meticulously adjusted pharmacokinetic profile and especially fine-tuned blood clearance kinetics are key characteristics of therapeutic radiopharmaceuticals. We, therefore, aimed to develop a method that allowed the estimation of blood clearance kinetics in vitro. For this purpose,
Identifiants
pubmed: 36145382
pii: ph15091161
doi: 10.3390/ph15091161
pmc: PMC9500755
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB824, projects B11 and Z01
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