Role of Caspases and Gasdermin A during HSV-1 Infection in Mice.
ASC
HSV-1
axon pruning
caspase-6
caspases
cell death
gasdermin A
keratinocyte
mice
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
13 09 2022
13 09 2022
Historique:
received:
20
08
2022
revised:
06
09
2022
accepted:
12
09
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Herpes simplex virus type 1 (HSV-1) infection can manifest locally as mucocutaneous lesions or keratitis and can also spread to the central nervous system to cause encephalitis. HSV-1 establishes a lifelong latent infection and neither cure nor vaccine is currently available. The innate immune response is the first line of defense against infection. Caspases and gasdermins are important components of innate immunity. Caspases are a family of cysteine proteases, most of which mediate regulated cell death. Gasdermins are a family of pore-forming proteins that trigger lytic cell death. To determine whether caspases or gasdermins contribute to innate immune defenses against HSV-1, we screened mice deficient in specific cell death genes. Our results indicate a modest role for caspase-6 in defense against HSV-1. Further,
Identifiants
pubmed: 36146839
pii: v14092034
doi: 10.3390/v14092034
pmc: PMC9504851
pii:
doi:
Substances chimiques
Gsdma3 protein, mouse
0
Pore Forming Cytotoxic Proteins
0
Proteins
0
Caspase 6
EC 3.4.22.-
Caspase 7
EC 3.4.22.-
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139304
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI119073
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133236
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR072694
Pays : United States
Organisme : NIH HHS
ID : AR072694, AI119073, AI133236, AI139304, and AI136920
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI133236
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136920
Pays : United States
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