NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals.
Molecular neuroscience
developmental neuroscience
functional aspects of cell biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
20
06
2022
revised:
26
07
2022
accepted:
30
08
2022
entrez:
23
9
2022
pubmed:
24
9
2022
medline:
24
9
2022
Statut:
epublish
Résumé
In the axon terminal, microtubule stability is decreased relative to the axon shaft. The dynamic microtubule plus ends found in the axon terminal have many functions, including serving as a docking site for the Cytoplasmic dynein motor. Here, we report an unexplored function of dynein in microtubule regulation in axon terminals: regulation of microtubule stability. Using a forward genetic screen, we identified a mutant with an abnormal axon terminal structure owing to a loss of function mutation in NudC. We show that, in the axon terminal, NudC is a chaperone for the protein Lis1. Decreased Lis1 in
Identifiants
pubmed: 36147950
doi: 10.1016/j.isci.2022.105072
pii: S2589-0042(22)01344-X
pmc: PMC9485903
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105072Subventions
Organisme : NICHD NIH HHS
ID : R01 HD072844
Pays : United States
Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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