Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer.

Humans Biomarkers, Tumor / genetics Carcinoma, Squamous Cell / diagnosis Head and Neck Neoplasms / diagnosis Human Papillomavirus Viruses Papillomavirus Infections / complications Prognosis Squamous Cell Carcinoma of Head and Neck / diagnosis Synaptogyrins
Diagnostic biomarkers HPV(+) HNSC Head Neck & Oral Cancers Prognostic biomarkers Tumor Immune Microenvironment biomarker

Journal

Cancer research communications
ISSN: 2767-9764
Titre abrégé: Cancer Res Commun
Pays: United States
ID NLM: 9918281580506676

Informations de publication

Date de publication:
09 2022
Historique:
entrez: 23 9 2022
pubmed: 24 9 2022
medline: 24 9 2022
Statut: ppublish

Résumé

Over 70% of oropharyngeal head and neck squamous cell carcinoma (HNSC) cases in the United States are positive for human papillomavirus (HPV) yet biomarkers for stratifying oropharyngeal head and neck squamous cell carcinoma (HNSC) patient risk are limited. We used immunogenomics to identify differentially expressed genes in immune cells of HPV(+) and HPV(-) squamous carcinomas. Candidate genes were tested in clinical specimens using both quantitative RT-PCR and IHC and validated by IHC using the Carolina Head and Neck Cancer Study (CHANCE) tissue microarray of HNSC cases. We performed multiplex immunofluorescent staining to confirm expression within the immune cells of HPV(+) tumors, receiver operating characteristic (ROC) curve analyses, and assessed survival outcomes. The neuronal gene

Identifiants

DOI: 10.1158/2767-9764.crc-21-0135 PMID: 36148399 PMC: PMC9491693
pubmed: 36148399
doi: 10.1158/2767-9764.crc-21-0135
pmc: PMC9491693
mid: NIHMS1831958
doi:

Substances chimiques

Biomarkers, Tumor 0
Synaptogyrins 0
SYNGR3 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

987-1004

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE030123
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA233333
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM119999
Pays : United States
Organisme : NIDCR NIH HHS
ID : F31 DE028749
Pays : United States
Organisme : NIDCR NIH HHS
ID : T90 DE021986
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA211056
Pays : United States
Organisme : NIDCR NIH HHS
ID : P50 DE030707
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215075
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA258451
Pays : United States
Organisme : NCI NIH HHS
ID : R41 CA246848
Pays : United States

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Auteurs

Ryan M Murphy (RM)

Graduate Curriculum in Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Jason Tasoulas (J)

Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Alessandro Porrello (A)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Miranda B Carper (MB)

Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Yi-Hsuan Tsai (YH)

Bioinformatics Core, Lineberger Comprehensive Cancer Center, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, NC, USA.

Alisha R Coffey (AR)

Bioinformatics Core, Lineberger Comprehensive Cancer Center, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, NC, USA.

Sunil Kumar (S)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Technology Development, Naveris Inc., Natick, MA, USA.

Peter Yf Zeng (PY)

Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Department of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.

Travis P Schrank (TP)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, Chapel Hill, NC, USA.

Bentley R Midkiff (BR)

Pathology Services Core, Lineberger Comprehensive Cancer Center, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, NC, USA.

Stephanie Cohen (S)

Pathology Services Core, Lineberger Comprehensive Cancer Center, UNC School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, Chapel Hill, NC, USA.

Ashley H Salazar (AH)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Michele C Hayward (MC)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

D Neil Hayes (DN)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Cancer Research, University of Tennessee Health Sciences, Memphis, Tennessee, USA.

Andrew Olshan (A)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, Chapel Hill, NC, USA.

Gaorav P Gupta (GP)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Radiation Oncology, UNC School of Medicine, Chapel Hill, NC, USA.

Anthony C Nichols (AC)

Department of Otolaryngology - Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.
Department of Oncology, University of Western Ontario, London, Ontario, Canada.

Wendell G Yarbrough (WG)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, Chapel Hill, NC, USA.
Department of Pathology and Lab Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, Chapel Hill, NC, USA.

Chad V Pecot (CV)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, Chapel Hill, NC, USA.

Antonio L Amelio (AL)

Division of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Cancer Cell Biology Program, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Papillomaviridae › Virus des Papillomavirus humains › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladies transmissibles › Maladies sexuellement transmissibles › Maladies sexuellement transmissibles virales › Infections à papillomavirus › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Diagnostic › Pronostic › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Tumor Cell Extrinsic Synaptogyrin 3 Expression...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Synaptogyrines › Tumor Cell Extrinsic Synaptogyrin 3 Expression...