Cerebral metabolic rate of oxygen (CMRO
Cerebral blood flow (CBF)
Cerebral metabolic rate of oxygen (CMRO(2))
Healthy adults
MRI
Neuronal activity
Simultaneous transcranial direct current stimulation (tDCS)
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
01 12 2022
01 12 2022
Historique:
received:
23
06
2022
revised:
06
09
2022
accepted:
16
09
2022
pubmed:
24
9
2022
medline:
19
10
2022
entrez:
23
9
2022
Statut:
ppublish
Résumé
Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive technique used for cortical excitability modulation. tDCS has been extensively investigated for its clinical applications; however further understanding of its underlying in-vivo physiological mechanisms remains a fundamental focus of current research. We investigated the simultaneous effects of tDCS on cerebral blood flow (CBF), venous blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO Twenty-three healthy participants (age = 35.6 ± 15.0 years old, 10 males) completed a simultaneous tDCS-MRI session in a 3 T scanner fitted with a 64-channels head coil. A MR-compatible tDCS device was used to acquire CBF, Yv and CMRO During tDCS, CBF significantly increased (57.10 ± 8.33 mL/100g/min) from baseline (53.67 ± 7.75 mL/100g/min; p < 0.0001) and remained elevated in post-tDCS (56.79 ± 8.70 mL/100g/min). Venous blood oxygenation levels measured in pre-tDCS (60.71 ± 4.12 %) did not significantly change across the three timepoints. The resulting CMRO tDCS has immediate effects on neuronal excitability, as measured by increased cerebral blood supply and oxygen consumption supporting increased neuronal firing. These findings provide a standard range of CBF and CMRO
Sections du résumé
BACKGROUND
Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive technique used for cortical excitability modulation. tDCS has been extensively investigated for its clinical applications; however further understanding of its underlying in-vivo physiological mechanisms remains a fundamental focus of current research.
OBJECTIVES
We investigated the simultaneous effects of tDCS on cerebral blood flow (CBF), venous blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO
METHODS
Twenty-three healthy participants (age = 35.6 ± 15.0 years old, 10 males) completed a simultaneous tDCS-MRI session in a 3 T scanner fitted with a 64-channels head coil. A MR-compatible tDCS device was used to acquire CBF, Yv and CMRO
RESULTS
During tDCS, CBF significantly increased (57.10 ± 8.33 mL/100g/min) from baseline (53.67 ± 7.75 mL/100g/min; p < 0.0001) and remained elevated in post-tDCS (56.79 ± 8.70 mL/100g/min). Venous blood oxygenation levels measured in pre-tDCS (60.71 ± 4.12 %) did not significantly change across the three timepoints. The resulting CMRO
CONCLUSIONS
tDCS has immediate effects on neuronal excitability, as measured by increased cerebral blood supply and oxygen consumption supporting increased neuronal firing. These findings provide a standard range of CBF and CMRO
Identifiants
pubmed: 36150457
pii: S0006-8993(22)00321-3
doi: 10.1016/j.brainres.2022.148097
pmc: PMC10335216
mid: NIHMS1905638
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
148097Subventions
Organisme : NIEHS NIH HHS
ID : 27300C0032
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111896
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG077422
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD094424
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112996
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA055427
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS101362
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108491
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS110041
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095123
Pays : United States
Organisme : NIGMS NIH HHS
ID : T34 GM137858
Pays : United States
Organisme : NIA NIH HHS
ID : R13 AG067684
Pays : United States
Organisme : NIDA NIH HHS
ID : 75N95020C00024
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA048502
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB017183
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Soterix Medical Inc. provided the tDCS equipment used for research use. The City University of New York holds patents on brain stimulation with MB as inventor. The City University of New York holds patents on brain stimulation with AD as inventor. AD is an employee of Soterix Medical Inc. AD has equity in Soterix Medical Inc. MB has equity in Soterix Medical Inc. MB consults, received grants, assigned inventions, and/or serves on the SAB of SafeToddles, Boston Scientific, GlaxoSmithKline, Biovisics, Mecta, Lumenis, Halo Neuroscience, Google-X, i-Lumen, Humm, Allergan (Abbvie), Apple.
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