α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease.
Nrf2
Parkinson's disease
aging
alpha-synuclein
ferroptosis
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
received:
01
07
2022
revised:
08
09
2022
accepted:
16
09
2022
pubmed:
24
9
2022
medline:
19
10
2022
entrez:
23
9
2022
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting millions each year. Most PD cases (∼90%) are sporadic, resulting from the age-dependent accumulation of pathogenic effects. One key pathological hallmark of PD progression is the accumulation of alpha-synuclein (α-syn), which has been shown to negatively affect neuronal function and viability. Here, using 3- and 6-month-old Nrf2
Identifiants
pubmed: 36150560
pii: S0891-5849(22)00597-4
doi: 10.1016/j.freeradbiomed.2022.09.015
pmc: PMC9841923
mid: NIHMS1855793
pii:
doi:
Substances chimiques
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Nfe2l2 protein, mouse
0
alpha-Synuclein
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-140Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES004940
Pays : United States
Organisme : NIEHS NIH HHS
ID : R35 ES031575
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Références
Free Radic Biol Med. 2019 Mar;133:221-233
pubmed: 30266679
Neurotherapeutics. 2012 Apr;9(2):297-314
pubmed: 22350713
NPJ Parkinsons Dis. 2020 Jul 9;6:15
pubmed: 32665974
Redox Biol. 2021 May;41:101896
pubmed: 33799121
J Neurosci Res. 2011 Jul;89(7):1091-102
pubmed: 21488084
JCI Insight. 2017 Apr 6;2(7):e90777
pubmed: 28405617
J Neurosci Res. 2002 Jun 1;68(5):568-78
pubmed: 12111846
Cell Death Differ. 2020 Oct;27(10):2781-2796
pubmed: 32341450
Free Radic Biol Med. 2008 Aug 1;45(3):242-55
pubmed: 18456002
Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:255-277
pubmed: 34637322
Aging Dis. 2021 Jul 1;12(4):964-982
pubmed: 34221542
Redox Biol. 2019 May;23:101107
pubmed: 30692038
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
J Alzheimers Dis. 2018;66(2):453-460
pubmed: 30320583
Front Mol Neurosci. 2019 Dec 05;12:299
pubmed: 31866823
Aging Cell. 2019 Dec;18(6):e13031
pubmed: 31432604
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:555-575
pubmed: 30256716
Curr Protoc Neurosci. 2010 Oct;Chapter 4:Unit 4.21
pubmed: 20938923
Med Res Rev. 2021 Mar;41(2):770-784
pubmed: 32656815
Antioxid Redox Signal. 2016 Mar 1;24(7):376-91
pubmed: 26564470
J Neurosci. 2004 Oct 20;24(42):9434-40
pubmed: 15496679
Regen Med. 2015;10(5):563-77
pubmed: 26237701
Mol Neurodegener. 2019 Jul 22;14(1):29
pubmed: 31331359
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3381-6
pubmed: 14985508