Transcriptomic Signatures of Hypomethylating Agent Failure in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia.

Humans Mice Animals Leukemia, Myelomonocytic, Chronic / drug therapy Transcriptome Myelodysplastic Syndromes / drug therapy Azacitidine / pharmacology Leukemia, Myelomonocytic, Juvenile / drug therapy

Journal

Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313

Informations de publication

Date de publication:
11 2022
Historique:
received: 08 05 2022
revised: 25 08 2022
accepted: 08 09 2022
pubmed: 24 9 2022
medline: 8 11 2022
entrez: 23 9 2022
Statut: ppublish

Résumé

Hypomethylating agents (HMAs) are the standard of care for myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML). HMA treatment failure is a major clinical problem and its mechanisms are poorly characterized. We performed RNA sequencing in CD34

Identifiants

DOI: 10.1016/j.exphem.2022.09.002 PMID: 36150563
pubmed: 36150563
pii: S0301-472X(22)00697-X
doi: 10.1016/j.exphem.2022.09.002
pii:
doi:

Substances chimiques

Azacitidine M801H13NRU

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

44-53

Informations de copyright

Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Conflict of Interest Disclosure The authors declare no competing interests.

Auteurs

Faezeh Darbaniyan (F)

Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.

Hong Zheng (H)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Rashmi Kanagal-Shamanna (R)

Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX.

Pamela Lockyer (P)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Guillermo Montalban-Bravo (G)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Marcos Estecio (M)

Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, X.

Yue Lu (Y)

Department of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, X.

Kelly A Soltysiak (KA)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Kelly S Chien (KS)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Hui Yang (H)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Koji Sasaki (K)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Caleb Class (C)

Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX; Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN.

Irene Ganan-Gomez (I)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Kim-Anh Do (KA)

Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX.

Guillermo Garcia-Manero (G)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.

Yue Wei (Y)

Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: ywei@mdanderson.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Eucaryotes › Animaux › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie myélomonocytaire chronique › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myélodysplasiques › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Cytidine › Azacitidine › Transcriptomic Signatures of Hypomethylating...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Maladies myélodysplasiques-myéloprolifératives › Leucémie myélomonocytaire juvénile › Transcriptomic Signatures of Hypomethylating...