Viral Capsid and Polymerase in Reoviridae.

Capsid / metabolism Capsid Proteins / chemistry Cryoelectron Microscopy RNA, Double-Stranded / metabolism RNA, Viral / genetics RNA-Dependent RNA Polymerase / genetics Reoviridae / genetics
Capsid Capsid layers Capsid proteins Core Double-stranded RNA (dsRNA) Inner Capsid Particle (ICP) RNA-dependent RNA polymerase (RdRp) Reoviridae Reovirus transcription Reoviruses

Journal

Sub-cellular biochemistry
ISSN: 0306-0225
Titre abrégé: Subcell Biochem
Pays: United States
ID NLM: 0316571

Informations de publication

Date de publication:
2022
Historique:
entrez: 23 9 2022
pubmed: 24 9 2022
medline: 28 9 2022
Statut: ppublish

Résumé

The members of the family Reoviridae (reoviruses) consist of 9-12 discrete double-stranded RNA (dsRNA) segments enclosed by single, double, or triple capsid layers. The outer capsid proteins of reoviruses exhibit the highest diversity in both sequence and structural organization. By contrast, the conserved RNA-dependent RNA polymerase (RdRp) structure in the conserved innermost shell in all reoviruses suggests that they share common transcriptional regulatory mechanisms. After reoviruses are delivered into the cytoplasm of a host cell, their inner capsid particles (ICPs) remain intact and serve as a stable nanoscale machine for RNA transcription and capping performed using enzymes in ICPs. Advances in cryo-electron microscopy have enabled the reconstruction at near-atomic resolution of not only the icosahedral capsid, including capping enzymes, but also the nonicosahedrally distributed complexes of RdRps within the capsid at different transcriptional stages. These near-atomic resolution structures allow us to visualize highly coordinated structural changes in the related enzymes, genomic RNA, and capsid protein during reovirus transcription. In addition, reoviruses encode their own enzymes for nascent RNA capping before RNA releasing from their ICPs.

Identifiants

DOI: 10.1007/978-3-031-00793-4_17 PMID: 36151388
pubmed: 36151388
doi: 10.1007/978-3-031-00793-4_17
doi:

Substances chimiques

Capsid Proteins 0
RNA, Double-Stranded 0
RNA, Viral 0
RNA-Dependent RNA Polymerase EC 2.7.7.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

525-552

Informations de copyright

© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.

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Auteurs

Hongrong Liu (H)

Key Laboratory for Matter Microstructure and Function of Hunan Province, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control, School of Physics and Electronics, Hunan Normal University, Changsha, China. hrliu@hunnu.edu.cn.

Lingpeng Cheng (L)

Key Laboratory for Matter Microstructure and Function of Hunan Province, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control, School of Physics and Electronics, Hunan Normal University, Changsha, China. lingpengcheng@hunnu.edu.cn.
School of Life Sciences, Tsinghua University, Beijing, China. lingpengcheng@hunnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Structures virales › Virion › Nucléocapside › Capside › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines de capside › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA replicase › Viral Capsid and Polymerase in Reoviridae.
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN double brin › Reoviridae › Viral Capsid and Polymerase in Reoviridae.