Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 09 2022
24 09 2022
Historique:
received:
11
08
2021
accepted:
09
09
2022
pubmed:
25
9
2022
medline:
28
9
2022
entrez:
24
9
2022
Statut:
epublish
Résumé
Infections by multidrug-resistant Enterobacteriaceae (MRE) are life-threatening to patients. The intestinal microbiome protects against MRE colonization, but antibiotics cause collateral damage to commensals and open the way to colonization and subsequent infection. Despite the significance of this problem, the specific commensals and mechanisms that restrict MRE colonization remain largely unknown. Here, by performing a multi-omic prospective study of hospitalized patients combined with mice experiments, we find that Lactobacillus is key, though not sufficient, to restrict MRE gut colonization. Lactobacillus rhamnosus and murinus increase the levels of Clostridiales bacteria, which induces a hostile environment for MRE growth through increased butyrate levels and reduced nutrient sources. This mechanism of colonization resistance, an interaction between Lactobacillus spp. and Clostridiales involving cooperation between microbiota members, is conserved in mice and patients. These results stress the importance of exploiting microbiome interactions for developing effective probiotics that prevent infections in hospitalized patients.
Identifiants
pubmed: 36153315
doi: 10.1038/s41467-022-33313-w
pii: 10.1038/s41467-022-33313-w
pmc: PMC9509339
doi:
Substances chimiques
Anti-Bacterial Agents
0
Butyrates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5617Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137269
Pays : United States
Informations de copyright
© 2022. The Author(s).
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