Dithranol as novel co-adjuvant for non-invasive dermal vaccination.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
24 Sep 2022
24 Sep 2022
Historique:
received:
29
01
2022
accepted:
30
08
2022
pubmed:
25
9
2022
medline:
25
9
2022
entrez:
24
9
2022
Statut:
epublish
Résumé
Transcutaneous immunization (TCI) utilizing the TLR7 agonist imiquimod (IMQ-TCI) induces T cell-driven protective immunity upon application onto intact skin. In our present work, we combine the anti-psoriatic agent dithranol with IMQ-TCI to boost vaccination efficacy (Dithranol/IMQ-based transcutaneous vaccination (DIVA)). Using ovalbumin-derived peptides as model antigens in mice, DIVA induced superior cytolytic CD8
Identifiants
pubmed: 36153349
doi: 10.1038/s41541-022-00530-9
pii: 10.1038/s41541-022-00530-9
pmc: PMC9509335
doi:
Types de publication
Journal Article
Langues
eng
Pagination
112Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : CRC1066
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 318346496
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : TR156-KS01
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 1066
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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