Axial impairment and falls in Parkinson's disease: 15 years of subthalamic deep brain stimulation.
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
24 Sep 2022
24 Sep 2022
Historique:
received:
28
04
2022
accepted:
30
08
2022
pubmed:
25
9
2022
medline:
25
9
2022
entrez:
24
9
2022
Statut:
epublish
Résumé
In this retrospective study, we longitudinally analyzed axial impairment and falls in people with Parkinson's disease (PD) and subthalamic nucleus deep brain stimulation (STN-DBS). Axial scores and falling frequency were examined at baseline, and 1, 10, and 15 years after surgery. Preoperative demographic and clinical data, including PD duration and severity, phenotype, motor and cognitive scales, medications, and vascular changes on neuroimaging were examined as possible risk factors through Kaplan-Meier and Cox regression analyses. Of 302 individuals examined before and at 1 year after surgery, 102 and 57 were available also at 10 and 15 years of follow-up, respectively. Axial scores were similar at baseline and at 1 year but worsened at 10 and 15 years. The prevalence rate of frequent fallers progressively increased from baseline to 15 years. Preoperative axial scores, frontal dysfunction and age at PD onset were risk factors for axial impairment progression after surgery. Axial scores, akinetic/rigid phenotype, age at disease onset and disease duration at surgery predicted frequent falls. Overall, axial signs progressively worsened over the long-term period following STN-DBS, likely related to the progression of PD, especially in a subgroup of subjects with specific risk factors.
Identifiants
pubmed: 36153351
doi: 10.1038/s41531-022-00383-y
pii: 10.1038/s41531-022-00383-y
pmc: PMC9509398
doi:
Types de publication
Journal Article
Langues
eng
Pagination
121Informations de copyright
© 2022. The Author(s).
Références
Neurology. 2021 Jun 2;:
pubmed: 34078713
N Engl J Med. 2013 Feb 14;368(7):610-22
pubmed: 23406026
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
J Neurol. 2021 Aug;268(8):2821-2830
pubmed: 33598766
J Neurosurg. 2019 Jan 11;131(6):1797-1804
pubmed: 30641837
Mov Disord. 2015 Sep;30(10):1407-13
pubmed: 26184453
Neurosurgery. 2018 Dec 1;83(6):1173-1182
pubmed: 29444300
Am J Epidemiol. 1989 Jan;129(1):125-37
pubmed: 2910056
JAMA. 2009 Jan 7;301(1):63-73
pubmed: 19126811
NPJ Parkinsons Dis. 2021 May 27;7(1):47
pubmed: 34045471
Ann Neurol. 2021 Nov;90(5):699-710
pubmed: 34235776
J Neurol Neurosurg Psychiatry. 2012 Jun;83(6):607-11
pubmed: 22362919
Clin Neurophysiol. 2021 Oct;132(10):2422-2430
pubmed: 34454269
Neurology. 1987 Sep;37(9):1539-42
pubmed: 3627454
Brain Stimul. 2016 Sep-Oct;9(5):774-779
pubmed: 27198578
Arch Neurol. 2011 Feb;68(2):165
pubmed: 20937936
Mov Disord. 2010 Nov 15;25(15):2649-53
pubmed: 21069833
NPJ Parkinsons Dis. 2015 Jun 11;1:15011
pubmed: 28409181
Brain. 2002 Nov;125(Pt 11):2408-17
pubmed: 12390968
J Mov Disord. 2020 May;13(2):127-132
pubmed: 32498496
Lancet Neurol. 2012 Feb;11(2):140-9
pubmed: 22239915
Neurology. 1967 May;17(5):427-42
pubmed: 6067254
Acta Neurol Scand. 2014 Nov;130(5):292-8
pubmed: 24495107
Mov Disord. 2003 Jul;18(7):738-50
pubmed: 12815652
Mov Disord. 2020 Aug;35(8):1369-1378
pubmed: 32246798
Neurology. 2002 Sep 24;59(6):932-4
pubmed: 12297584
Acta Neurol Scand. 2005 May;111(5):301-8
pubmed: 15819709
Curr Opin Neurol. 2004 Aug;17(4):405-15
pubmed: 15247535
J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):174-9
pubmed: 7876847
J Neurol. 2009 Feb;256(2):225-33
pubmed: 19242649
Eur J Neurol. 2006 Sep;13(9):963-71
pubmed: 16930362
Neurology. 2019 May 28;92(22):e2559-e2570
pubmed: 31043471
Nat Rev Neurol. 2015 Feb;11(2):98-110
pubmed: 25582445
Brain. 2010 Sep;133(9):2664-76
pubmed: 20802207
Lancet Neurol. 2010 Jun;9(6):581-91
pubmed: 20434403
Mov Disord. 2014 Jun;29(7):949-53
pubmed: 24532106
Front Hum Neurosci. 2020 Feb 11;14:1
pubmed: 32116598
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Parkinsonism Relat Disord. 2019 May;62:91-97
pubmed: 30704853
Brain. 2005 Oct;128(Pt 10):2240-9
pubmed: 15975946
Arch Neurol. 2011 Dec;68(12):1550-6
pubmed: 21825213
N Engl J Med. 2006 Aug 31;355(9):896-908
pubmed: 16943402
Mov Disord. 2006 Jun;21 Suppl 14:S290-304
pubmed: 16892449
Neurology. 1999 Jul 13;53(1):85-90
pubmed: 10408541
Acta Neurol Scand. 2011 Jun;123(6):424-9
pubmed: 21492098
Gait Posture. 2002 Aug;16(1):1-14
pubmed: 12127181
Clin Neurol Neurosurg. 2017 Mar;154:43-48
pubmed: 28113102
J Neurol. 2020 Oct;267(10):2949-2960
pubmed: 32488298
J Neurosurg. 2012 Jun;116(6):1347-56
pubmed: 22424564
Eur Neurol. 2007;58(4):218-23
pubmed: 17823535
PLoS One. 2020 Sep 11;15(9):e0238936
pubmed: 32915893
Mov Disord. 2009 Mar 15;24(4):557-63
pubmed: 19097175
Sci Rep. 2017 Jun 20;7(1):3921
pubmed: 28634343
J Neurol Neurosurg Psychiatry. 2011 Oct;82(10):1112-8
pubmed: 21593513
Int J Surg. 2014 Dec;12(12):1495-9
pubmed: 25046131
Ann Neurol. 2021 Mar;89(3):587-597
pubmed: 33349939
Parkinsonism Relat Disord. 2015 Mar;21(3):236-42
pubmed: 25572498
Arch Clin Neuropsychol. 1997;12(3):269-75
pubmed: 14588419
Parkinsonism Relat Disord. 2010 Nov;16(9):582-4
pubmed: 20678955