Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 Outpatients.


Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
26 10 2022
Historique:
pubmed: 27 9 2022
medline: 29 10 2022
entrez: 26 9 2022
Statut: ppublish

Résumé

Primary care urgently needs treatments for coronavirus disease 2019 (COVID-19) patients because current options are limited, while these patients who do not require hospitalization encompass more than 90% of the people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we evaluated a throat spray containing three

Identifiants

pubmed: 36154666
doi: 10.1128/spectrum.01682-22
pmc: PMC9604152
doi:

Substances chimiques

Antiviral Agents 0
Oral Sprays 0

Types de publication

Randomized Controlled Trial Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0168222

Références

Gut Microbes. 2022 Jan-Dec;14(1):2018899
pubmed: 35014600
Front Microbiol. 2017 Nov 29;8:2372
pubmed: 29238339
Antiviral Res. 2012 Jan;93(1):138-43
pubmed: 22120759
JAMA Netw Open. 2022 Apr 1;5(4):e226269
pubmed: 35385087
Allergy. 2019 Jan;74(1):100-110
pubmed: 29888398
EBioMedicine. 2022 Jan;75:103788
pubmed: 34954658
Cell. 2020 May 28;181(5):1036-1045.e9
pubmed: 32416070
N Engl J Med. 2021 Oct 7;385(15):1355-1371
pubmed: 34496194
Lancet. 2021 Sep 4;398(10303):843-855
pubmed: 34388395
Trends Mol Med. 2021 Jun;27(6):538-553
pubmed: 33879402
Sci Rep. 2016 Jun 16;6:27870
pubmed: 27306590
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Curr Pharm Des. 2018;24(6):710-717
pubmed: 29345577
Nat Commun. 2017 Aug 1;8(1):167
pubmed: 28761099
JAMA. 2022 Apr 5;327(13):1236-1246
pubmed: 35285853
Lancet Infect Dis. 2022 Feb;22(2):183-195
pubmed: 34756186
Eur J Epidemiol. 2022 May;37(5):549-561
pubmed: 35644003
Cell Rep. 2020 May 26;31(8):107674
pubmed: 32460009
Nat Immunol. 2022 Feb;23(2):186-193
pubmed: 35105982
BMJ Open. 2020 Jun 17;10(6):e039674
pubmed: 32554730
Lancet. 2021 Mar 20;397(10279):1063-1074
pubmed: 33676597
Br J Gen Pract. 2021 Jul 29;71(709):e634-e642
pubmed: 33979303
JAMA. 2021 Feb 16;325(7):632-644
pubmed: 33475701
Infection. 2021 Oct;49(5):927-934
pubmed: 33970430
N Engl J Med. 2021 Dec 2;385(23):e81
pubmed: 34587383
Sci Rep. 2020 Oct 9;10(1):16939
pubmed: 33037304
J Virol Methods. 2021 Feb;288:114025
pubmed: 33227340
mSphere. 2019 Nov 27;4(6):
pubmed: 31776238
Allergy Asthma Immunol Res. 2021 Jul;13(4):560-575
pubmed: 34212544
Nat Med. 2021 Jan;27(1):86-93
pubmed: 33257893
Front Med (Lausanne). 2020 Jul 07;7:389
pubmed: 32733907
Cochrane Database Syst Rev. 2015 Feb 03;(2):CD006895
pubmed: 25927096
Nature. 2022 Mar;603(7901):493-496
pubmed: 35102312
Lancet Infect Dis. 2022 Feb;22(2):152-153
pubmed: 34756187
Fam Pract. 2022 Jan 19;39(1):92-98
pubmed: 34448859
Microb Biotechnol. 2021 May;14(3):859-869
pubmed: 33507624
JMIR Res Protoc. 2021 May 28;10(5):e24811
pubmed: 33882023
Int J Infect Dis. 2021 Apr;105:304-306
pubmed: 33636357
Microbiol Spectr. 2022 Oct 26;10(5):e0168222
pubmed: 36154666
Open Forum Infect Dis. 2021 Mar 01;8(3):ofab090
pubmed: 33796601
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
pubmed: 24912386
Nat Med. 2020 May;26(5):681-687
pubmed: 32327758
JAMA. 2021 Aug 10;326(6):490-498
pubmed: 34269813

Auteurs

Ilke De Boeck (I)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Eline Cauwenberghs (E)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Irina Spacova (I)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Thies Gehrmann (T)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Tom Eilers (T)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Lize Delanghe (L)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Stijn Wittouck (S)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Peter A Bron (PA)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Tim Henkens (T)

Yun NV, Niel, Belgium.

Imane Gamgami (I)

Yun NV, Niel, Belgium.

Alix Simons (A)

Yun NV, Niel, Belgium.

Ingmar Claes (I)

Yun NV, Niel, Belgium.

Joachim Mariën (J)

Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Evolutionary Ecology Group, Department of Biology, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Kevin K Ariën (KK)

Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Department of Biomedical Sciences, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Diana Bakokimi (D)

Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Katherine Loens (K)

Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerpgrid.5284.b, Antwerp, Belgium.
Department of Microbiology, University Hospital Antwerp, Edegem, Belgium.

Kevin Jacobs (K)

Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerpgrid.5284.b, Antwerp, Belgium.

Margareta Ieven (M)

Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerpgrid.5284.b, Antwerp, Belgium.
Department of Microbiology, University Hospital Antwerp, Edegem, Belgium.

Patricia Bruijning-Verhagen (P)

Julius Centre for Health Sciences and Primary Care, Department of Epidemiology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Peter Delputte (P)

Laboratory of Microbiology, Parasitology and Hygiene, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Samuel Coenen (S)

Family Medicine and Population Health (FAMPOP), University of Antwerpgrid.5284.b, Antwerp, Belgium.
Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerpgrid.5284.b, Antwerp, Belgium.

Veronique Verhoeven (V)

Family Medicine and Population Health (FAMPOP), University of Antwerpgrid.5284.b, Antwerp, Belgium.

Sarah Lebeer (S)

Research Group Environmental Ecology and Applied Microbiology, Department of Bioscience Engineering, University of Antwerpgrid.5284.b, Antwerp, Belgium.

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