Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor.
Hox
axial identity
brachyury
developmental biology
embryonic stem cells
human
mouse
neural crest
neuromesodermal progenitors
regenerative medicine
stem cells
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
26 09 2022
26 09 2022
Historique:
received:
27
09
2021
accepted:
25
09
2022
pubmed:
27
9
2022
medline:
12
10
2022
entrez:
26
9
2022
Statut:
epublish
Résumé
The neural crest (NC) is an important multipotent embryonic cell population and its impaired specification leads to various developmental defects, often in an anteroposterior (A-P) axial level-specific manner. The mechanisms underlying the correct A-P regionalisation of human NC cells remain elusive. Recent studies have indicated that trunk NC cells, the presumed precursors of childhood tumour neuroblastoma, are derived from neuromesodermal-potent progenitors of the postcranial body. Here we employ human embryonic stem cell differentiation to define how neuromesodermal progenitor (NMP)-derived NC cells acquire a posterior axial identity. We show that TBXT, a pro-mesodermal transcription factor, mediates early posterior NC/spinal cord regionalisation together with WNT signalling effectors. This occurs by TBXT-driven chromatin remodelling via its binding in key enhancers within
Identifiants
pubmed: 36154671
doi: 10.7554/eLife.74263
pii: 74263
pmc: PMC9536837
doi:
pii:
Substances chimiques
Transcription Factors
0
Banques de données
GEO
['GSE184227', 'GSE184622', 'GSE184620']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P000444/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V002163/1
Pays : United Kingdom
Informations de copyright
© 2022, Gogolou et al.
Déclaration de conflit d'intérêts
AG, CS, IG, FW, IM, MW, TF, MG, AB, CB, FH, MT, MG, AT No competing interests declared
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