Role of gremlin-1 in the pathophysiology of the adipose tissues.
Adipose tissue
Gremlin-1
Metabolic disorders
Obesity
Journal
Cytokine & growth factor reviews
ISSN: 1879-0305
Titre abrégé: Cytokine Growth Factor Rev
Pays: England
ID NLM: 9612306
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
12
08
2022
accepted:
12
09
2022
pubmed:
27
9
2022
medline:
8
2
2023
entrez:
26
9
2022
Statut:
ppublish
Résumé
Gremlin-1 is a secreted bone morphogenetic protein (BMP) antagonist playing a pivotal role in the regulation of tissue formation and embryonic development. Since its first identification in 1997, gremlin-1 has been shown to be a multifunctional factor involved in wound healing, inflammation, cancer and tissue fibrosis. Among others, the activity of gremlin-1 is mediated by its interaction with BMPs or with membrane receptors such as the vascular endothelial growth factor receptor 2 (VEGFR2) or heparan sulfate proteoglycans (HSPGs). Growing evidence has highlighted a central role of gremlin-1 in the homeostasis of the adipose tissue (AT). Of note, gremlin-1 is involved in AT dysfunction during type 2 diabetes, obesity and non-alcoholic fatty liver disease (NAFLD) metabolic disorders. In this review we discuss recent findings on gremlin-1 involvement in AT biology, with particular attention to its role in metabolic diseases, to highlight its potential as a prognostic marker and therapeutic target.
Identifiants
pubmed: 36155165
pii: S1359-6101(22)00074-0
doi: 10.1016/j.cytogfr.2022.09.004
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Bone Morphogenetic Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-60Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.