MCU controls melanoma progression through a redox-controlled phenotype switch.
MCU
ROS
calcium
melanoma
mitochondria
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
07 11 2022
07 11 2022
Historique:
revised:
29
08
2022
received:
28
01
2022
accepted:
29
08
2022
pubmed:
27
9
2022
medline:
9
11
2022
entrez:
26
9
2022
Statut:
ppublish
Résumé
Melanoma is the deadliest of skin cancers and has a high tendency to metastasize to distant organs. Calcium and metabolic signals contribute to melanoma invasiveness; however, the underlying molecular details are elusive. The MCU complex is a major route for calcium into the mitochondrial matrix but whether MCU affects melanoma pathobiology was not understood. Here, we show that MCU
Identifiants
pubmed: 36156348
doi: 10.15252/embr.202254746
pmc: PMC9638851
doi:
Substances chimiques
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e54746Subventions
Organisme : NCI NIH HHS
ID : P30 CA010815
Pays : United States
Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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