Anticancer activity of an Artemisia annua L. hydroalcoholic extract on canine osteosarcoma cell lines.

Animals Dogs Artemisia annua / chemistry Artemisinins / pharmacology Bone Neoplasms / veterinary Cell Line Dog Diseases Iron Osteosarcoma / drug therapy Plant Extracts / pharmacology Tandem Mass Spectrometry / methods
Artemisia annua Balloning phenotype Canine osteosarcoma cell lines Ferroptosis Iron Lipid peroxidation

Journal

Research in veterinary science
ISSN: 1532-2661
Titre abrégé: Res Vet Sci
Pays: England
ID NLM: 0401300

Informations de publication

Date de publication:
20 Dec 2022
Historique:
received: 16 05 2022
revised: 06 09 2022
accepted: 12 09 2022
pubmed: 27 9 2022
medline: 2 11 2022
entrez: 26 9 2022
Statut: ppublish

Résumé

Since ancient times, Artemisia annua (A. annua) has been used as a medicinal plant in Traditional Chinese Medicine. In addition, recent studies have investigated the cytotoxic effects of A. annua extracts towards cancer cells. The leading aim of the present research is to evaluate the cytotoxic effects of an hydroalcoholic extract of A. annua on two canine osteosarcoma (OSA) cell lines, OSCA-8 and OSCA-40, focusing on the possible involvement of ferroptosis. The quantitative determination of artemisinin concentration in the extract, culture medium and OSA cells was carried out through the use of an instrumental analytical method based on liquid chromatography coupled with spectrophotometric detection and tandem mass spectrometry (LC-DAD-MS/MS). OSCA-8 and OSCA-40 were exposed to different dilutions of the extract for the EC

Identifiants

DOI: 10.1016/j.rvsc.2022.09.012 PMID: 36156377
pubmed: 36156377
pii: S0034-5288(22)00293-4
doi: 10.1016/j.rvsc.2022.09.012
pii:
doi:

Substances chimiques

artemisinin 9RMU91N5K2
Artemisinins 0
Iron E1UOL152H7
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

476-484

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Roberta Salaroli (R)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: roberta.salaroli@unibo.it.

Giulia Andreani (G)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: giulia.andreani2@unibo.it.

Chiara Bernardini (C)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: chiara.bernardini5@unibo.it.

Augusta Zannoni (A)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: augusta.zannoni@unibo.it.

Debora La Mantia (D)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: debora.lamantia2@unibo.it.

Michele Protti (M)

Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy. Electronic address: michele.protti2@unibo.it.

Monica Forni (M)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: monica.forni@unibo.it.

Laura Mercolini (L)

Research Group of Pharmaco-Toxicological Analysis (PTA Lab), Department of Pharmacy and Biotechnology (FaBiT), Alma Mater Studiorum - University of Bologna, 40126 Bologna, Italy. Electronic address: laura.mercolini@unibo.it.

Gloria Isani (G)

Department of Veterinary Medical Sciences (DIMEVET), Alma Mater Studiorum - University of Bologna, 40064 Ozzano Emilia, Bologna, Italy. Electronic address: gloria.isani@unibo.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Artemisia › Artemisia annua › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Artémisinines › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Tumeurs osseuses › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Maladies de l'animal › Maladies des chiens › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Ostéosarcome › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Anticancer activity of an Artemisia annua L....
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Anticancer activity of an Artemisia annua L....