Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
05 12 2022
05 12 2022
Historique:
received:
18
01
2022
revised:
29
03
2022
accepted:
01
09
2022
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
28
9
2022
Statut:
ppublish
Résumé
Neonatal herpes simplex virus (nHSV) infections often result in significant mortality and neurological morbidity despite antiviral drug therapy. Maternally transferred herpes simplex virus (HSV)-specific antibodies reduce the risk of clinically overt nHSV, but this observation has not been translationally applied. Using a neonatal mouse model, we tested the hypothesis that passive transfer of HSV-specific human mAbs can prevent mortality and morbidity associated with nHSV. The mAbs were expressed in vivo via vectored immunoprophylaxis or recombinantly. Through these maternally derived routes or through direct administration to pups, diverse mAbs to HSV glycoprotein D protected against neonatal HSV-1 and HSV-2 infection. Using in vivo bioluminescent imaging, both pre- and post-exposure mAb treatment significantly reduced viral load in mouse pups. Together these studies support the notion that HSV-specific mAb-based therapies could prevent or improve HSV infection outcomes in neonates.
Identifiants
pubmed: 36156707
pii: 213499
doi: 10.1084/jem.20220110
pmc: PMC9516843
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Viral
0
Antiviral Agents
0
Glycoproteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY009083
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI098681
Pays : United States
Organisme : NIDA NIH HHS
ID : DP2 DA040254
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007363
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI145825
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI147714
Pays : United States
Informations de copyright
© 2022 Backes et al.
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