Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
pubmed:
27
9
2022
medline:
14
3
2023
entrez:
26
9
2022
Statut:
ppublish
Résumé
Inflammation plays a critical role in the pathogenesis of endometriosis. We aimed to study the proinflammatory effect of Chemerin chemokine-like receptor 1 (CMKLR1) in patients with endometriosis. Sixty patients with endometriosis and 50 healthy controls were recruited in this study for the collection of endometrial samples and peritoneal fluid. The expression levels of CMKLR1, IL-6, MCP-1, and TNF-α in peritoneal fluid and endometrial tissues were detected by ELISA, qRT-PCR, and immunohistochemical staining. Human endometrial stromal cells (HESCs) were used to measure the Chemerin-induced CMKLR1 activation and inflammatory responses. CMKLR1 level was significantly up-regulated in peritoneal fluid and endometrial tissues in patients with endometriosis. Interestingly, CMKLR1 overexpression positively correlated with pro-inflammatory cytokines and chemokine in both peritoneal fluid and ectopic endometrium. Chemerin treatment increased the expression of CMKLR1, and aggravated inflammatory responses in HESCs. CMKLR1 is up-regulated in peritoneal fluid and endometrial tissues, and promotes the inflammatory responses in of endometriosis.
Identifiants
pubmed: 36156768
pii: HH-18-523
doi: 10.14670/HH-18-523
doi:
Substances chimiques
Cytokines
0
Chemokines
0
CMKLR1 protein, human
0
Receptors, Chemokine
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
329-337Informations de copyright
©The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License.
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