A cross-sectional assessment of frailty, falls and perceptions of ageing in people living with HIV using an mHealth platform.


Journal

HIV medicine
ISSN: 1468-1293
Titre abrégé: HIV Med
Pays: England
ID NLM: 100897392

Informations de publication

Date de publication:
04 2023
Historique:
received: 23 02 2022
accepted: 30 08 2022
medline: 12 4 2023
pubmed: 27 9 2022
entrez: 26 9 2022
Statut: ppublish

Résumé

To evaluate frailty, falls and perceptions of ageing among clinically stable individuals with HIV, engaged with remote healthcare delivered via a novel smartphone application. This was a multi-centre European cross-sectional, questionnaire-based sub-study of EmERGE participants. Frailty was assessed using the five-item FRAIL scale. Present criteria were summed and categorized as follows: 0, robust; 1-2, pre-frail; 3-5, frail. Falls history and EQ-5D-5L quality of life measure were completed. Participants were asked their felt age and personal satisfaction with ageing. A total of 1373 participated, with a mean age of 45 (± 9.8) years. Frailty was uncommon at 2%; 12.4% fell in the previous year, 58.8% of these recurrently. Mood symptoms and pain were prevalent, at 43.3% and 31.8%, respectively. Ageing satisfaction was high at 76.4%, with 74.6% feeling younger than their chronological age; the mean felt age was 39.3 years. In multivariable analysis, mood symptoms and pain were positively associated with frailty, falls and ageing dissatisfaction. An increase in pain severity and mood symptoms were respectively associated with 34% and 63% increased odds of pre-frailty/frailty. An increment in pain symptoms was associated with a 71% increase in odds of falling. Pain was associated with ageing poorly, as were mood symptoms, with odds of dissatisfaction increasing by 34% per increment in severity. Although uncommon, frailty, falls and ageing dissatisfaction were seen in a younger cohort with medically stable HIV infection using a remote care model, promoting screening as advocated by European guidelines. These were more common in those with pain or mood symptoms, which should be proactively managed in clinical care and explored further in future research.

Identifiants

pubmed: 36156841
doi: 10.1111/hiv.13409
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

431-441

Informations de copyright

© 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.

Références

May MT, Gompels M, Delpech V, et al. Impact on life expectancy of HIV-1 positive individuals of CD4+ cell count and viral load response to antiretroviral therapy: UK cohort study. AIDS. 2014;28:1193-1202.
Baylis A, Buck D, Anderson J, Jabbal J, Ross S. The future of HIV services in England shaping the response to changing needs. Joint United Nations Programme on HIV/AIDS (UNAIDS); 2017.
Guaraldi G, Milic J, Martinez E, et al. HIV care models during the COVID-19 era. Clin Infect Dis. 2020;19:47. doi:10.1093/cid/ciaa1864
Cooper T, Woodward B, Alom S, Harky A. Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: a systematic review. HIV Med. 2020;21:21-577. doi:10.1111/hiv.12911
Unaids. UNAIDS report on the global AIDS epidemic. 2013. http://files.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf. (Accessed 31 March 2017).
Smit M, Brinkman K, Geerlings S, et al. Future challenges for clinical care of an ageing population infected with HIV: a modelling study. Lancet Infect Dis. 2015;15:810-818.
Tavoschi L, Gomes Dias J, Pharris A, et al. New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004-15: an analysis of surveillance data. Lancet HIV. 2017;4:e514-e521.
European Centre for Disease Prevention and Control. HIV/AIDS surveillance in Europe 2020. European Centre for Disease Prevention and Control; 2020.
Greene M, Covinsky KE, Valcour V, et al. Geriatric syndromes in older HIV-infected adults. J Acquir Immune Defic Syndr. 2015;69:161-167.
Levett TJ, Cresswell FV, Malik MA, Fisher M, Wright J. Systematic review of prevalence and predictors of frailty in individuals with human immunodeficiency virus. J Am Geriatr Soc. 2016;64:1006-1014.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381:752-762.
European Clinical AIDS Society. EACS guidelines version 10.0 2019. https://www.eacsociety.org/files/2019_guidelines-10.0_final.pdf.
European Clinical AIDS Society. EACS guidelines version 11.0; 2021. https://www.eacsociety.org/guidelines/eacs-guidelines/.
Janssen MF, Pickard AS, Golicki D, et al. Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study. Qual Life Res. 2013;22:22-1727. doi:10.1007/s11136-012-0322-4
Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12:29-37.
Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16:601-608.
Sonnega A, Faul JD, Ofstedal MB, Langa KM, Phillips JWR, Weir DR. Cohort profile: the health and retirement study (HRS). Int J Epidemiol. 2014;43:576-585.
Akgün KM, Tate JP, Crothers K, et al. An adapted frailty-related phenotype and the VACS index as predictors of hospitalization and mortality in HIV-infected and uninfected individuals. J Acquir Immune Defic Syndr. 2014;67:397-404.
Manfredi G, Midão L, Paúl C, Cena C, Duarte M, Costa E. Prevalence of frailty status among the European elderly population: findings from the survey of health, aging and retirement in Europe. Geriatr Gerontol Int. 2019;19:723-729.
Yeoh H-L, Cheng A, Palmer C, Crowe SM, Hoy JF. Frailty in men living with HIV: a cross-sectional comparison of three frailty instruments. Antivir Ther. 2018;23:117-127. doi:10.3851/IMP3185
Lorenz DR, Mukerji SS, Misra V, et al. Multimorbidity networks associated with frailty among middle-aged and older people with HIV. AIDS. 2021;35:2451-2461.
Faller JW, Pereira D d N, de Souza S, Nampo FK, Orlandi F d S, Matumoto S. Instruments for the detection of frailty syndrome in older adults: a systematic review. PLoS One. 2019;14:e0216166.
Morley JE, Vellas B, van Kan GA, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14:392-397.
Hawkins KL, Brown TT, Margolick JB, Erlandson KM. Geriatric syndromes: new frontiers in HIV and sarcopenia. AIDS. 2017;31(Suppl 2):S137-S146.
Premaor MO, Compston JE. People living with HIV and fracture risk. Osteoporos Int. 2020;31:1633-1644.
Tassiopoulos K, Abdo M, Wu K, et al. Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults. AIDS. 2017;31:2287-2294.
Waters L, Patterson B, Scourfield A, et al. A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience. Int J STD AIDS. 2012;23:546-552.
Westerhof GJ, Wurm S. Longitudinal research on subjective aging, health, and longevity: current evidence and new directions for research. Annu Rev Gerontol Geriatr. 2015;35:145-165.
Nieves-Lugo K, Ware D, Friedman MR, et al. Self-perception of aging among HIV-positive and HIV-negative participants in the multicenter AIDS cohort study. AIDS Care. 2020;32:818-828.
Shinan-Altman S, Werner P. Subjective age and its correlates among middle-aged and older adults. Int J Aging Hum Dev. 2019;88:3-21.
Kohli M, Kamalyan L, Pasipanodya EC, et al. Felt age discrepancy differs by HIV Serostatus: a secondary analysis. J Assoc Nurses AIDS Care. 2020;31:587-597.
Fumaz CR, Muñoz-Moreno JA, Ferrer MJ, et al. Emotional impact of premature aging symptoms in long-term treated HIV-infected subjects. J Acquir Immune Defic Syndr. 2012;59:e5-e8.
Parker R, Stein DJ, Jelsma J. Pain in people living with HIV/AIDS: a systematic review. J Int AIDS Soc. 2014;17:18719.
Merlin JS, Westfall AO, Chamot E, et al. Pain is independently associated with impaired physical function in HIV-infected patients. Pain Med. 2013;14:1985-1993.
Scott W, Arkuter C, Kioskli K, et al. Psychosocial factors associated with persistent pain in people with HIV: a systematic review with meta-analysis. Pain. 2018;159:2461-2476.
Uebelacker LA, Weisberg RB, Herman DS, Bailey GL, Pinkston-Camp MM, Stein MD. Chronic pain in HIV-infected patients: relationship to depression, substance use, and mental health and pain treatment. Pain Med. 2015;16:1870-1881.
Erlandson KM, Allshouse AA, Jankowski CM, et al. Risk factors for falls in HIV-infected persons. J Acquir Immune Defic Syndr. 2012;61:484-489.
Petit N, Enel P, Ravaux I, et al. Frail and pre-frail phenotype is associated with pain in older HIV-infected patients. Medicine. 2018;97:e9852.
Rezaei S, Ahmadi S, Rahmati J, et al. Global prevalence of depression in HIV/AIDS: a systematic review and meta-analysis. BMJ Support Palliat Care. 2019;9:404-412.
Kooij KW, Wit FWNM, Schouten J, et al. HIV infection is independently associated with frailty in middle-aged HIV type 1-infected individuals compared with similar but uninfected controls. AIDS. 2016;30:241-250.
Soysal P, Veronese N, Thompson T, et al. Relationship between depression and frailty in older adults: a systematic review and meta-analysis. Ageing Res Rev. 2017;36:78-87.
National Institute of Health and Care Excellence. Multimorbidity: Clinical Assessment and Management: NICE Guideline [NG56]. National Institute of Health and Care Excellence; 2016. https://www.nice.org.uk/guidance/ng56
Lazarus JV, Safreed-Harmon K, Barton SE, et al. Beyond viral suppression of HIV - the new quality of life frontier. BMC Med. 2016;14:94.
Mitnitski AB, Graham JE, Mogilner AJ, Rockwood K. Frailty, fitness and late-life mortality in relation to chronological and biological age. BMC Geriatr. 2002;2:1-8.
Dodds R, Kuh D, Aihie Sayer A, Cooper R. Physical activity levels across adult life and grip strength in early old age: updating findings from a British birth cohort. Age Ageing. 2013;42:794-798.
Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27:17-26.

Auteurs

Tom J Levett (TJ)

Brighton & Sussex Medical School, Brighton, UK.

Jaime H Vera (JH)

Brighton & Sussex Medical School, Brighton, UK.

Christopher I Jones (CI)

Brighton & Sussex Medical School, Brighton, UK.

Stephen Bremner (S)

Brighton & Sussex Medical School, Brighton, UK.

Agathe Leon (A)

Fundació Clínic per a la Recerca, Barcelona, Spain.

Josip Begovac (J)

Klinika za Infektivne Bolesti, Zagreb, Croatia.

Ludwig Apers (L)

Instituut Voor Tropische Geneeskunde, Antwerp, Belgium.

Margarida Borges (M)

Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Sime Zekan (S)

Klinika za Infektivne Bolesti, Zagreb, Croatia.

Eugenio Teofilo (E)

Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Felipe Garcia (F)

Fundació Clínic per a la Recerca, Barcelona, Spain.

Jennifer Whetham (J)

University Hospitals Sussex NHS Foundation Trust, Brighton, UK.

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