Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.

cardioprotection cardiotoxicity glucose hyperglycaemia protein kinase C (PKC) time-dependent

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2022
Historique:
received: 18 07 2022
accepted: 15 08 2022
entrez: 26 9 2022
pubmed: 27 9 2022
medline: 27 9 2022
Statut: epublish

Résumé

Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In

Identifiants

pubmed: 36158799
doi: 10.3389/fcvm.2022.997013
pmc: PMC9489859
doi:

Types de publication

Journal Article

Langues

eng

Pagination

997013

Informations de copyright

Copyright © 2022 Brennan, Esposito, Abdelaziz, Martin, Makwana, Sims, Squire, Sharma, Chadwick and Rainbow.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Sean Brennan (S)

Department of Cardiovascular, Metabolic Medicine and Liverpool Centre for Cardiovascular Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

Simona Esposito (S)

Department of Cardiovascular, Metabolic Medicine and Liverpool Centre for Cardiovascular Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, United Kingdom.

Muhammad I M Abdelaziz (MIM)

Department of Cardiovascular, Metabolic Medicine and Liverpool Centre for Cardiovascular Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

Christopher A Martin (CA)

Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, United Kingdom.

Samir Makwana (S)

Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, United Kingdom.

Mark W Sims (MW)

Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, United Kingdom.

Iain B Squire (IB)

Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, United Kingdom.
Leicester NIHR Biomedical Research Centre, Glenfield General Hospital, Leicester, United Kingdom.

Parveen Sharma (P)

Department of Cardiovascular, Metabolic Medicine and Liverpool Centre for Cardiovascular Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

Amy E Chadwick (AE)

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, Liverpool, United Kingdom.

Richard D Rainbow (RD)

Department of Cardiovascular, Metabolic Medicine and Liverpool Centre for Cardiovascular Sciences, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

Classifications MeSH