Mycophenolate Mofetil for Severe IgA Vasculitis Nephropathy in Children: An Observational Study.
Children
IGA vasculitis
nephritis
nephrotic syndrome
pediatric
proteinuria
renal failure
Journal
Kidney medicine
ISSN: 2590-0595
Titre abrégé: Kidney Med
Pays: United States
ID NLM: 101756300
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
27
9
2022
Statut:
epublish
Résumé
Individuals with IgA vasculitis nephritis (IGAVN) may develop rapidly progressive glomerulonephritis and/or nephrotic-range proteinuria, which are associated with worse prognosis. We report our experience of treatment of children with IGAVN with nephrotic-range proteinuria. Case series. We retrospectively analyzed all children who presented with IGAVN, cutaneous purpura, and nephrotic-range proteinuria from January 1, 2000 until December 31, 2018. We evaluated time required to achieve remission of proteinuria, resolution of hematuria, and glomerular filtration rate (GFR) at 12 months and last follow-up. Twelve patients, 8 boys and 4 girls, mean age 7.5 years (range 4-15) were included in the study. Mean urinary protein to creatinine ratio (UPC) was 12.5 ± 8.7 mg/mg and GFR 90.7 ± 19.1 mL/min/1.73 m Retrospective study, single-center experience, no standard immunosuppressive protocol, lack of control group. Remission can be achieved in patients with IGAVN and nephrotic-range proteinuria using mycophenolate mofetil-based immunosuppression. Magnitude of proteinuria is a key laboratory finding that correlates with time to achieve remission. Prolonged follow-up of patients with severe IGAVN is warranted.
Identifiants
pubmed: 36159165
doi: 10.1016/j.xkme.2022.100534
pii: S2590-0595(22)00156-X
pmc: PMC9490199
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100534Informations de copyright
© 2022 The Authors.
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