Maturation of circulating Ly6C


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 17 06 2022
accepted: 03 08 2022
entrez: 26 9 2022
pubmed: 27 9 2022
medline: 28 9 2022
Statut: epublish

Résumé

Autoimmune diseases affecting the CNS not only overcome immune privilege mechanisms that protect neural tissues but also peripheral immune tolerance mechanisms towards self. Together with antigen-specific T cells, myeloid cells are main effector cells in CNS autoimmune diseases such as multiple sclerosis, but the relative contributions of blood-derived monocytes and the tissue resident macrophages to pathology and repair is incompletely understood. Through the study of oxidized mannan-conjugated myelin oligodendrocyte glycoprotein 35-55 (OM-MOG), we show that peripheral maturation of Ly6C

Identifiants

pubmed: 36159850
doi: 10.3389/fimmu.2022.972003
pmc: PMC9501702
doi:

Substances chimiques

Antigens, Ly 0
Ccr2 protein, mouse 0
Ly-6C antigen, mouse 0
Mannans 0
Mog protein, mouse 0
Myelin-Oligodendrocyte Glycoprotein 0
Peptides 0
Receptors, CCR2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

972003

Informations de copyright

Copyright © 2022 Dagkonaki, Papalambrou, Avloniti, Gkika, Evangelidou, Androutsou, Tselios and Probert.

Déclaration de conflit d'intérêts

M-EA was employed by the company Vianex S.A. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Anastasia Dagkonaki (A)

Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

Athina Papalambrou (A)

Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

Maria Avloniti (M)

Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

Areti Gkika (A)

Department of Chemistry, University of Patras, Patras, Greece.

Maria Evangelidou (M)

Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

Maria-Eleni Androutsou (ME)

Research and Development Department, Vianex PLC, Nea Erythrea, Greece.

Theodore Tselios (T)

Department of Chemistry, University of Patras, Patras, Greece.

Lesley Probert (L)

Laboratory of Molecular Genetics, Department of Immunology, Hellenic Pasteur Institute, Athens, Greece.

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Classifications MeSH