Diagnosis, treatment, and current concepts in the endoscopic management of gastroenteropancreatic neuroendocrine neoplasms.


Journal

World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448

Informations de publication

Date de publication:
14 Sep 2022
Historique:
received: 11 04 2022
revised: 29 06 2022
accepted: 22 08 2022
entrez: 26 9 2022
pubmed: 27 9 2022
medline: 28 9 2022
Statut: ppublish

Résumé

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare tumors derived from the neuroendocrine cell system, which that have increased in incidence and prevalence in recent years. Despite improvements in radiological and metabolic imaging, endoscopy still plays a pivotal role in the number of GEP-NENs. Tumor detection, characterization, and staging are essential in management and treatment planning. Upper and lower gastrointestinal (GI) endoscopy is essential for correct localization of the primary tumor site of GI NENs. Endoscopic ultrasonography (EUS) has an important role in the imaging and tissue acquisition of pancreatic NENs and locoregional staging of GI neuroendocrine tumors. Correct staging and histological diagnosis have important prognostic implications. Endoscopic operating techniques allow the removal of small GI NENs in the early stage of mucosal or submucosal invasion of the intestinal wall. Preoperative EUS-guided techniques may help the surgeon locate small and deep tumors, thus avoiding formal pancreatic resections in favor of parenchymal-sparing surgery. Finally, locoregional ablative treatments have been proposed in recent studies with promising results in selected patients.

Identifiants

pubmed: 36160644
doi: 10.3748/wjg.v28.i34.4943
pmc: PMC9494936
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4943-4958

Informations de copyright

©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

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Auteurs

Giuseppe Iabichino (G)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Milena Di Leo (M)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Monica Arena (M)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Giovanni Giuseppe Rubis Passoni (GG)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Elisabetta Morandi (E)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Francesca Turpini (F)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Paolo Viaggi (P)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy.

Carmelo Luigiano (C)

Gastroenterology Section, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria 89124, Italy.

Luca De Luca (L)

Digestive Endoscopy Unit, ASST Santi Paolo e Carlo, Milano 20144, Italy. lucadeluca1210@gmail.com.

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