Adjuvant chemoradiotherapy
Adjuvant chemoradiotherapy
Adjuvant chemotherapy
Gastroesophageal junction
Recurrence
Siewert type II/III
Survival
Journal
World journal of gastrointestinal oncology
ISSN: 1948-5204
Titre abrégé: World J Gastrointest Oncol
Pays: China
ID NLM: 101532470
Informations de publication
Date de publication:
15 Aug 2022
15 Aug 2022
Historique:
received:
06
05
2022
revised:
19
06
2022
accepted:
22
07
2022
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
27
9
2022
Statut:
ppublish
Résumé
For Siewert type II/III adenocarcinoma of gastroesophageal junction (AGE), the efficacy of adjuvant chemoradiotherapy (CRT) after D2/R0 resection remains uncertain. To determine whether CRT was superior to chemotherapy (CT) alone after D2/R0 resection for locally advanced Siewert type II/III AGE. We identified 316 locally advanced Siewert type II/III AGE patients who were treated with D2/R0 resection at National Cancer Center from 2011 to 2018. 57 patients received adjuvant CRT and 259 patients received adjuvant CT. We followed patients for overall survival (OS), relapse-free survival, and recurrence pattern. Five-year OS rates of the CRT group and the CT group for all patients were 66.7% and 41.9% ( For locally advanced Siewert type III AGE, adjuvant CRT may prolong OS and reduce the regional recurrence rate.
Sections du résumé
BACKGROUND
BACKGROUND
For Siewert type II/III adenocarcinoma of gastroesophageal junction (AGE), the efficacy of adjuvant chemoradiotherapy (CRT) after D2/R0 resection remains uncertain.
AIM
OBJECTIVE
To determine whether CRT was superior to chemotherapy (CT) alone after D2/R0 resection for locally advanced Siewert type II/III AGE.
METHODS
METHODS
We identified 316 locally advanced Siewert type II/III AGE patients who were treated with D2/R0 resection at National Cancer Center from 2011 to 2018. 57 patients received adjuvant CRT and 259 patients received adjuvant CT. We followed patients for overall survival (OS), relapse-free survival, and recurrence pattern.
RESULTS
RESULTS
Five-year OS rates of the CRT group and the CT group for all patients were 66.7% and 41.9% (
CONCLUSION
CONCLUSIONS
For locally advanced Siewert type III AGE, adjuvant CRT may prolong OS and reduce the regional recurrence rate.
Identifiants
pubmed: 36160743
doi: 10.4251/wjgo.v14.i8.1540
pmc: PMC9412933
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1540-1551Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Références
Cancer Radiother. 2011 Oct;15(6-7):555-9
pubmed: 21802333
Esophagus. 2017;14(1):1-36
pubmed: 28111535
Gastric Cancer. 2011 Jun;14(2):101-12
pubmed: 21573743
J Clin Oncol. 2015 Oct 1;33(28):3130-6
pubmed: 25559811
Trials. 2021 Oct 30;22(1):753
pubmed: 34717717
Br J Surg. 2017 Jun;104(7):877-884
pubmed: 28245053
Lancet Oncol. 2006 Aug;7(8):644-51
pubmed: 16887481
J Clin Oncol. 2012 Jan 20;30(3):268-73
pubmed: 22184384
N Engl J Med. 2001 Sep 6;345(10):725-30
pubmed: 11547741
Ann Oncol. 2021 Mar;32(3):368-374
pubmed: 33278599
J Gastric Cancer. 2019 Jun;19(2):148-156
pubmed: 31245159
Ann Surg. 2016 Jan;263(1):88-95
pubmed: 25647058
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Ann Surg Oncol. 2014 Apr;21(4):1107-14
pubmed: 24306660
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
pubmed: 26808342
Ann Surg. 2000 Sep;232(3):353-61
pubmed: 10973385
Lancet Oncol. 2013 Nov;14(12):e535-47
pubmed: 24176572
J Am Coll Surg. 1999 Dec;189(6):594-601
pubmed: 10589596
Cancer Commun (Lond). 2021 Aug;41(8):747-795
pubmed: 34197702
Lancet. 2020 Aug 29;396(10251):635-648
pubmed: 32861308
Radiat Oncol. 2019 Jul 17;14(1):128
pubmed: 31315683
J Clin Oncol. 2011 Nov 20;29(33):4387-93
pubmed: 22010012
Lancet Oncol. 2015 Sep;16(9):1090-1098
pubmed: 26254683
J Surg Oncol. 2016 Dec;114(7):859-864
pubmed: 27511744
World J Gastrointest Oncol. 2019 Aug 15;11(8):567-578
pubmed: 31435459
J Clin Oncol. 2009 Feb 20;27(6):851-6
pubmed: 19139439