inPhocus: Current State and Challenges of Phage Research in Singapore.
antimicrobial resistance
ectolysin
filamentous phages
metagenomics
recombinant phage proteins
Journal
PHAGE (New Rochelle, N.Y.)
ISSN: 2641-6549
Titre abrégé: Phage (New Rochelle)
Pays: United States
ID NLM: 101768955
Informations de publication
Date de publication:
01 Mar 2022
01 Mar 2022
Historique:
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
27
9
2022
Statut:
ppublish
Résumé
Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.
Identifiants
pubmed: 36161195
doi: 10.1089/phage.2022.29028.nkv
pii: 10.1089/phage.2022.29028.nkv
pmc: PMC9436264
doi:
Types de publication
Journal Article
Langues
eng
Pagination
6-11Informations de copyright
Copyright 2022, Mary Ann Liebert, Inc., publishers.
Déclaration de conflit d'intérêts
No competing financial interests exist.
Références
J Heart Lung Transplant. 2019 Apr;38(4):475-476
pubmed: 30661974
J Med Microbiol. 2018 Mar;67(3):296-307
pubmed: 29458674
Nat Biotechnol. 2021 May;39(5):578-585
pubmed: 33349699
Nat Rev Microbiol. 2021 Aug;19(8):514-527
pubmed: 33785903
Viruses. 2018 Jun 07;10(6):
pubmed: 29875339
Antibiotics (Basel). 2022 Jan 28;11(2):
pubmed: 35203772
FEMS Microbiol Rev. 2015 Jul;39(4):465-87
pubmed: 25670735
Viruses. 2021 Jun 21;13(6):
pubmed: 34205687
Drug Discov Today. 2018 Apr;23(4):848-856
pubmed: 29326076
Quant Biol. 2020 Mar;8(1):64-77
pubmed: 34084563
Microbiome. 2021 Feb 1;9(1):37
pubmed: 33522966
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7280-7289
pubmed: 27671070
Front Microbiol. 2020 Nov 25;11:574739
pubmed: 33324362
Am J Transplant. 2019 Sep;19(9):2631-2639
pubmed: 31207123
BMC Microbiol. 2012 Mar 22;12:41
pubmed: 22439788
Cell Host Microbe. 2019 Feb 13;25(2):195-209
pubmed: 30763534
Front Microbiol. 2014 Dec 02;5:654
pubmed: 25520708
Antimicrob Agents Chemother. 2018 Jan 25;62(2):
pubmed: 29180523
EBioMedicine. 2016 Jan 05;4:124-37
pubmed: 26981577
ISME J. 2009 Mar;3(3):271-82
pubmed: 19005496
Lancet. 2022 Feb 12;399(10325):629-655
pubmed: 35065702
Front Cell Infect Microbiol. 2021 Jun 04;11:643214
pubmed: 34150671
Viruses. 2021 Oct 12;13(10):
pubmed: 34696479
J Antimicrob Chemother. 2018 Dec 1;73(12):3398-3404
pubmed: 30215762
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1419-27
pubmed: 24706926
Lancet Infect Dis. 2021 Mar;21(3):427-436
pubmed: 32949500
Nat Biotechnol. 2019 Aug;37(8):937-944
pubmed: 31359005
Cell. 2021 Feb 18;184(4):1098-1109.e9
pubmed: 33606979
Infect Dis Clin North Am. 2020 Dec;34(4):773-819
pubmed: 33011051
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0082421
pubmed: 34662188
Lancet Infect Dis. 2019 Jan;19(1):35-45
pubmed: 30292481
Viruses. 2021 Aug 15;13(8):
pubmed: 34452479