Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model.
endocytosis
focal adhesions
integrins
myotubular myopathy
phosphoinositides
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
04 10 2022
04 10 2022
Historique:
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
28
9
2022
Statut:
ppublish
Résumé
X-linked centronuclear myopathy (XLCNM) is a severe human disease without existing therapies caused by mutations in the phosphoinositide 3-phosphatase MTM1. Loss of MTM1 function is associated with muscle fiber defects characterized by impaired localization of β-integrins and other components of focal adhesions. Here we show that defective focal adhesions and reduced active β-integrin surface levels in a cellular model of XLCNM are rescued by loss of phosphatidylinositiol 3-kinase C2β (PI3KC2β) function. Inactivation of the
Identifiants
pubmed: 36161941
doi: 10.1073/pnas.2202236119
pmc: PMC9549396
doi:
Substances chimiques
Integrins
0
Phosphatidylinositol 3-Kinase
EC 2.7.1.137
Protein Tyrosine Phosphatases, Non-Receptor
EC 3.1.3.48
myotubularin
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2202236119Références
Nature. 2016 Jan 21;529(7586):408-12
pubmed: 26760201
Trends Mol Med. 2012 Jun;18(6):317-27
pubmed: 22578719
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18763-8
pubmed: 19846786
Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R285-92
pubmed: 12925573
Cell Rep. 2015 Jan 20;10(3):398-413
pubmed: 25600874
Brain. 2022 Jul 29;145(7):2313-2331
pubmed: 35786744
Adv Biol Regul. 2017 Jan;63:49-58
pubmed: 27666502
PLoS Genet. 2011 Feb 10;7(2):e1001295
pubmed: 21347281
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8910-5
pubmed: 10900271
Nat Rev Mol Cell Biol. 2022 May 19;:
pubmed: 35589852
Am J Pathol. 2012 Sep;181(3):961-8
pubmed: 22841819
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15060-5
pubmed: 12391329
Nat Cell Biol. 2021 Oct;23(10):1073-1084
pubmed: 34616024
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11066-11071
pubmed: 30291191
Science. 2021 Dec 10;374(6573):eabk0410
pubmed: 34882480
Dev Cell. 2022 Jul 25;57(14):1694-1711.e7
pubmed: 35809565
Nat Genet. 1996 Jun;13(2):175-82
pubmed: 8640223
Mol Cell Biol. 2010 Sep;30(18):4463-79
pubmed: 20624912
Nature. 2013 Jul 11;499(7457):233-7
pubmed: 23823722
Neuromuscul Disord. 2021 Oct;31(10):1004-1012
pubmed: 34736623
Cell Rep. 2015 Dec 1;13(9):1881-94
pubmed: 26655903
J Cell Physiol. 2006 Mar;206(3):586-93
pubmed: 16222711
Nat Commun. 2018 Sep 20;9(1):3825
pubmed: 30237420
J Cell Biol. 2018 Jun 4;217(6):1929-1940
pubmed: 29632027
Nat Med. 2016 Aug;22(8):889-96
pubmed: 27376575
Physiol Rev. 2013 Jul;93(3):1019-137
pubmed: 23899561
Nat Rev Mol Cell Biol. 2009 Jan;10(1):21-33
pubmed: 19197329
Mol Cell Biol. 2007 Nov;27(22):7906-17
pubmed: 17875942
J Cell Biol. 2016 Nov 21;215(4):445-456
pubmed: 27872252
Nat Chem Biol. 2022 Sep 15;:
pubmed: 36109648
Nat Cell Biol. 2019 Sep;21(9):1093-1101
pubmed: 31451768
Nat Cell Biol. 2015 Nov;17(11):1412-21
pubmed: 26436690
Acta Neuropathol. 2022 Sep;144(3):537-563
pubmed: 35844027
Mol Biol Cell. 2012 Aug;23(15):2905-16
pubmed: 22648170
Trends Cell Biol. 2019 Apr;29(4):339-359
pubmed: 30691999
Nature. 2006 Oct 12;443(7112):651-7
pubmed: 17035995
J Cell Sci. 2001 Jun;114(Pt 12):2255-63
pubmed: 11493665
Biochem Soc Trans. 2020 Feb 28;48(1):83-93
pubmed: 32065228
Hum Mol Genet. 2000 Sep 22;9(15):2223-9
pubmed: 11001925
Science. 2017 Jun 2;356(6341):968-972
pubmed: 28572395
Nat Cell Biol. 2019 Feb;21(2):122-132
pubmed: 30602723
Biochem J. 2014 Nov 1;463(3):413-27
pubmed: 25177796
Nat Commun. 2017 Jun 07;8:15661
pubmed: 28589938
Biochem J. 2009 Jul 29;422(1):23-35
pubmed: 19508231
PLoS Genet. 2009 Feb;5(2):e1000372
pubmed: 19197364
Sci Transl Med. 2019 Mar 20;11(484):
pubmed: 30894500
Traffic. 2012 Apr;13(4):610-25
pubmed: 22222055
J Clin Invest. 2014 Mar;124(3):1350-63
pubmed: 24569376
Nat Commun. 2018 Nov 19;9(1):4849
pubmed: 30451841
Dev Cell. 2003 May;4(5):673-85
pubmed: 12737803
J Cell Biol. 2010 Aug 9;190(3):407-25
pubmed: 20696708
J Neuromuscul Dis. 2018;5(4):387-406
pubmed: 30103348
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4206-11
pubmed: 20160082
Nat Cell Biol. 2018 Feb;20(2):198-210
pubmed: 29358706
J Biol Chem. 2004 Feb 20;279(8):7304-12
pubmed: 14660569
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9051-5
pubmed: 7692444
J Clin Invest. 2016 Sep 1;126(9):3613-25
pubmed: 27548528