Genetic adaptation of skin pigmentation in highland Tibetans.
Tibetan
UV radiation
adaptation
high altitude
pigmentation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
04 10 2022
04 10 2022
Historique:
entrez:
26
9
2022
pubmed:
27
9
2022
medline:
28
9
2022
Statut:
ppublish
Résumé
Strong ultraviolet (UV) radiation at high altitude imposes a serious selective pressure, which may induce skin pigmentation adaptation of indigenous populations. We conducted skin pigmentation phenotyping and genome-wide analysis of Tibetans in order to understand the underlying mechanism of adaptation to UV radiation. We observe that Tibetans have darker baseline skin color compared with lowland Han Chinese, as well as an improved tanning ability, suggesting a two-level adaptation to boost their melanin production. A genome-wide search for the responsible genes identifies
Identifiants
pubmed: 36161951
doi: 10.1073/pnas.2200421119
pmc: PMC9552612
doi:
Substances chimiques
Melanins
0
Acyltransferases
EC 2.3.-
glycerone-phosphate O-acyltransferase
EC 2.3.1.42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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