Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells.
AuNPs, Gold nanoparticles
BIOT-CPP-PEG-AuNPs, Biotinylated cell-penetrating peptides polyethylene glycol gold nanoparticles
BIOT-NFL-PEG-AuNPs, Biotinylated NFL-peptide polyethylene glycol gold nanoparticles
BIOT-NFL-peptide
BIOT-TAT-PEG-AuNPs, Biotinylated TAT-peptide polyethylene glycol gold nanoparticles
BIOT-TAT-peptide
BIOT-Vim-PEG-AuNPs, Biotinylated Vim-peptide polyethylene glycol gold nanoparticles
BIOT-Vim-peptide
CPP, Cell-penetrating peptides
GBM, Glioblastoma
Gold nanoparticles
NFL-peptide, NFL-TBS.40-63, or Neuro Filament Low subunit Tubulin Binding Site 40-63
PEG-AuNPs, Polyethylene glycol gold nanoparticles
Rat glioblastoma cells
TBS, Tubulin Binding Sites
TEM, Transmission electron microscopy
Transmission electron microscopy
Vim-peptide, Vim-TBS.58-81, or Vimentin Tubulin Binding Site 58-81
Journal
International journal of pharmaceutics: X
ISSN: 2590-1567
Titre abrégé: Int J Pharm X
Pays: Netherlands
ID NLM: 101753452
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
05
09
2022
accepted:
06
09
2022
entrez:
27
9
2022
pubmed:
28
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
Targeting, detecting, and destroying selectively cancer cells or specific organelles is a major challenge of nanomedicine. Recently, a new methodology was conceived to synthesize gold nanoparticles combined with a peptide having a C-terminal biotin (BIOT-NFL-peptide). This methodology called "Method IN" allows specific interactions between the BIOT-NFL-peptide, the polyethylene glycol diacid (PEG-COOH) and the gold salt (Au III) to produce multifunctional hybrid nano-carriers called BIOT-NFL-PEG-AuNPs. Here, we show that it is possible to use this strategy to synthesize multifunctional hybrid nano-carriers with other cell-penetrating peptides including TAT and Vim-peptides.
Identifiants
pubmed: 36164551
doi: 10.1016/j.ijpx.2022.100129
pii: S2590-1567(22)00018-4
pmc: PMC9508353
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100129Informations de copyright
© 2022 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest, with respect to the research, authorship, and/or publication of this article.
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