Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules.
Biological sciences
Evolutionary biology
Evolutionary processes
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
04
05
2022
revised:
26
07
2022
accepted:
31
08
2022
entrez:
27
9
2022
pubmed:
28
9
2022
medline:
28
9
2022
Statut:
epublish
Résumé
The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened available vertebrate genome data and found that GPR84 is present in vertebrates for more than 500 million years but absent in birds and a pseudogene in bats. Cloning and functional characterization of several mammalian GPR84 orthologs in combination with evolutionary and model-based structural analyses revealed evidence for positive selection of bear GPR84 orthologs. Naturally occurring human GPR84 variants are most frequent in Asian populations causing a loss of function. Further, we identified
Identifiants
pubmed: 36164652
doi: 10.1016/j.isci.2022.105087
pii: S2589-0042(22)01359-1
pmc: PMC9508565
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105087Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Trends Microbiol. 2017 Apr;25(4):293-303
pubmed: 27979499
Dis Model Mech. 2012 Jan;5(1):38-47
pubmed: 22228790
J Microbiol Methods. 2002 Aug;50(3):283-9
pubmed: 12031578
Nat Protoc. 2016 Aug;11(8):1554-71
pubmed: 27466713
Nucleic Acids Res. 2017 Mar 17;45(5):2936
pubmed: 27923934
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Clin Exp Immunol. 2015 May;180(2):165-77
pubmed: 25560985
J Biochem. 2015 May;157(5):311-20
pubmed: 25425658
Lancet. 2020 Feb 22;395(10224):565-574
pubmed: 32007145
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
J Agric Food Chem. 2008 Dec 24;56(24):11578-83
pubmed: 19090708
Chembiochem. 2010 Jul 26;11(11):1552-62
pubmed: 20572249
Dev Comp Immunol. 2014 Aug;45(2):252-8
pubmed: 24704214
Gut. 2022 May;71(5):928-937
pubmed: 34083384
Adv Pharmacol. 2014;70:81-119
pubmed: 24931193
Am J Pathol. 2018 May;188(5):1132-1148
pubmed: 29454750
Front Microbiol. 2015 Apr 28;6:383
pubmed: 25972860
Anim Sci J. 2020 Jan;91(1):e13357
pubmed: 32219956
Annu Rev Genomics Hum Genet. 2001;2:373-400
pubmed: 11701655
Science. 2021 Jun 18;372(6548):
pubmed: 34140358
Nature. 2014 Jan 9;505(7482):174-9
pubmed: 24402279
Nucleic Acids Res. 2001 Jan 1;29(1):308-11
pubmed: 11125122
Front Immunol. 2020 Jan 24;11:26
pubmed: 32117225
Annu Rev Pharmacol Toxicol. 2014;54:165-84
pubmed: 24111540
Annu Rev Microbiol. 2001;55:165-99
pubmed: 11544353
J Biol Chem. 2013 Nov 8;288(45):32194-32210
pubmed: 24056371
Mol Cell Biol. 1983 Feb;3(2):280-9
pubmed: 6300662
Nature. 2019 Dec;576(7785):106-111
pubmed: 31802016
Cell Res. 2021 Nov;31(11):1176-1189
pubmed: 34561620
J Med Chem. 2020 Mar 12;63(5):2391-2410
pubmed: 31721581
Genetics. 2010 Sep;186(1):295-308
pubmed: 20592267
Nat Rev Drug Discov. 2020 Jun;19(6):374
pubmed: 32494048
Tissue Barriers. 2021 Apr 3;9(2):1883965
pubmed: 33632074
Cell Commun Signal. 2020 Feb 26;18(1):31
pubmed: 32102673
ACS Pharmacol Transl Sci. 2021 Sep 07;4(5):1598-1613
pubmed: 34661077
DNA Cell Biol. 2020 Nov;39(11):1926-1937
pubmed: 33001759
BMC Evol Biol. 2008 May 27;8:162
pubmed: 18505555
Br J Pharmacol. 2022 Jul;179(14):3529-3541
pubmed: 32869860
J Exp Biol. 2021 Jul 1;224(13):
pubmed: 34114000
Nat Rev Microbiol. 2016 Aug 11;14(9):576-88
pubmed: 27510864
Mol Biol Evol. 2005 May;22(5):1208-22
pubmed: 15703242
Trends Biochem Sci. 2001 Nov;26(11):679-84
pubmed: 11701327
Int J Neuropsychopharmacol. 2018 Oct 1;21(10):962-977
pubmed: 30085126
Mol Cell. 2021 Mar 18;81(6):1147-1159.e4
pubmed: 33548201
Nature. 2016 Aug 25;536(7617):484-7
pubmed: 27525504
Nat Rev Genet. 2004 Aug;5(8):589-97
pubmed: 15266341
Pharmacol Res. 2022 Feb;176:106047
pubmed: 34968686
Cell. 2019 Mar 21;177(1):184-199
pubmed: 30901539
Cell. 2015 Jan 15;160(1-2):20-35
pubmed: 25533784
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8666-71
pubmed: 20421465
Viruses. 2019 Feb 23;11(2):
pubmed: 30813403
Nature. 2015 Aug 13;524(7564):173-179
pubmed: 26147082
Trends Pharmacol Sci. 2006 Feb;27(2):92-6
pubmed: 16406086
Methods Enzymol. 2002;343:329-71
pubmed: 11665578
J Neurosci. 2021 Jun 16;41(24):5219-5228
pubmed: 33941648
Nat Genet. 2018 Feb;50(2):270-277
pubmed: 29358652
Proteins. 2021 Nov;89(11):1577-1586
pubmed: 34272892
J Med Chem. 2017 May 11;60(9):3636-3655
pubmed: 28406627
PLoS Pathog. 2015 Jul 16;11(7):e1004986
pubmed: 26181439
Genome Biol. 2002 Oct 17;3(11):RESEARCH0063
pubmed: 12429062
Cell Metab. 2020 Jul 7;32(1):31-43
pubmed: 32640245
PLoS Genet. 2019 May 23;15(5):e1008145
pubmed: 31120900
Science. 2010 Nov 19;330(6007):1091-5
pubmed: 21097933
Sci Total Environ. 2021 Feb 1;754:142372
pubmed: 33254850
Front Immunol. 2018 Jun 20;9:1419
pubmed: 29973940
Protein Sci. 2021 Jan;30(1):70-82
pubmed: 32881101
Trends Biochem Sci. 2009 Nov;34(11):540-52
pubmed: 19836958
J Biol Chem. 2013 Apr 12;288(15):10684-91
pubmed: 23449982
Mol Biol Evol. 2015 May;32(5):1342-53
pubmed: 25697341
Mol Biol Evol. 2015 Mar;32(3):820-32
pubmed: 25540451
J Mol Biol. 2001 Mar 30;307(3):799-813
pubmed: 11273702
Annu Rev Pharmacol Toxicol. 2006;46:481-519
pubmed: 16402913
Science. 2019 Apr 12;364(6436):178-181
pubmed: 30975887
Genome Biol. 2015 Jan 29;16:21
pubmed: 25723810
Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):381-416
pubmed: 12382069
BMC Microbiol. 2017 Dec 04;17(1):226
pubmed: 29202699
Chem Rev. 2011 Jan 12;111(1):160-73
pubmed: 21166386
ACS Chem Biol. 2019 Sep 20;14(9):2055-2064
pubmed: 31465201
Mol Biol Evol. 2018 Mar 1;35(3):773-777
pubmed: 29301006
PLoS Genet. 2020 May 26;16(5):e1008749
pubmed: 32453742
Exp Mol Med. 2018 Aug 16;50(8):1-9
pubmed: 30115904
Sci Rep. 2017 Dec 20;7(1):17953
pubmed: 29263400
Clin Chem. 2003 Jul;49(7):1149-53
pubmed: 12816912
Nat Rev Genet. 2005 Feb;6(2):95-108
pubmed: 15716906
Gene. 1999 Jul 8;234(2):177-86
pubmed: 10395891
Mol Cell Endocrinol. 2017 Jul 5;449:3-11
pubmed: 27899324
Fish Shellfish Immunol. 2019 Jan;84:1098-1099
pubmed: 30414894
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Chem Rev. 2011 Dec 14;111(12):PR438-535
pubmed: 22165845
Mol Pharmacol. 2003 Jun;63(6):1256-72
pubmed: 12761335
Nucleic Acids Res. 2017 Jul 3;45(W1):W408-W415
pubmed: 28582569
Front Immunol. 2018 Sep 20;9:2112
pubmed: 30294323
FASEB J. 2019 Nov;33(11):12264-12276
pubmed: 31415180
Nat Struct Mol Biol. 2005 Apr;12(4):287-8
pubmed: 15809647
Hum Hered. 2003;55(4):171-8
pubmed: 14566095
J Biol Chem. 2006 Nov 10;281(45):34457-64
pubmed: 16966319
J Leukoc Biol. 2001 Jun;69(6):1045-52
pubmed: 11404393
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):959-63
pubmed: 14732697
Appl Environ Microbiol. 2004 Jan;70(1):262-7
pubmed: 14711650
Sci Rep. 2017 Apr 19;7:46487
pubmed: 28422140
Pharmaceuticals (Basel). 2015 Nov 25;8(4):816-35
pubmed: 26610524
Annu Rev Biochem. 2018 Jun 20;87:897-919
pubmed: 29925258
Int J Med Sci. 2013;10(5):508-14
pubmed: 23532623
ACS Omega. 2018 Mar 31;3(3):3365-3383
pubmed: 30023867
Front Physiol. 2017 Aug 21;8:601
pubmed: 28871231
Front Pharmacol. 2018 Mar 12;9:222
pubmed: 29593543
Nature. 2008 Sep 25;455(7212):497-502
pubmed: 18818650
J Biol Chem. 2007 Jan 5;282(1):518-25
pubmed: 17079233
Mol Interv. 2007 Feb;7(1):17-25
pubmed: 17339603
Nat Ecol Evol. 2017 Sep;1(9):1370-1378
pubmed: 28890940
Gigascience. 2014 Dec 11;3(1):32
pubmed: 25685332