Clinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort.
COPD
overdose
prospective cohort study
suicide deaths
tobacco smoking
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
17
02
2022
revised:
11
08
2022
accepted:
03
09
2022
pmc-release:
01
02
2024
pubmed:
28
9
2022
medline:
14
2
2023
entrez:
27
9
2022
Statut:
ppublish
Résumé
Studies have shown that COPD and smoking are associated with increased suicide risk. To date, there are no prospective studies examining suicide risk among individuals with smoking exposure along a spectrum of pulmonary diseases ranging from normal spirometry to severe COPD. Which clinical variables predict death by suicide or overdose of indeterminate intent in a large cohort of individuals with smoking exposure within the Genetic Epidemiology of COPD (COPDGene) study? We studied data from 9,930 participants involved in COPDGene, a multisite, prospective cohort study of individuals with smoking exposure. Primary cause of adjudicated deaths was identified by using death certificates, family reports, and medical records. Time to death by suicide/overdose was examined as the primary outcome in Cox regression models including age, sex, race, BMI, pack-years, current smoking status, airflow limitation (FEV The cohort was 47% female and 33% Black (67% White); they had a mean ± SD age of 59.6 ± 9.0 years and a mean FEV In this well-characterized cohort of individuals with smoking exposure with and without COPD, risk factors for suicide/overdose were identified that emphasize the subjective experience of illness over objective assessments of lung function.
Sections du résumé
BACKGROUND
Studies have shown that COPD and smoking are associated with increased suicide risk. To date, there are no prospective studies examining suicide risk among individuals with smoking exposure along a spectrum of pulmonary diseases ranging from normal spirometry to severe COPD.
RESEARCH QUESTION
Which clinical variables predict death by suicide or overdose of indeterminate intent in a large cohort of individuals with smoking exposure within the Genetic Epidemiology of COPD (COPDGene) study?
STUDY DESIGN AND METHODS
We studied data from 9,930 participants involved in COPDGene, a multisite, prospective cohort study of individuals with smoking exposure. Primary cause of adjudicated deaths was identified by using death certificates, family reports, and medical records. Time to death by suicide/overdose was examined as the primary outcome in Cox regression models including age, sex, race, BMI, pack-years, current smoking status, airflow limitation (FEV
RESULTS
The cohort was 47% female and 33% Black (67% White); they had a mean ± SD age of 59.6 ± 9.0 years and a mean FEV
INTERPRETATION
In this well-characterized cohort of individuals with smoking exposure with and without COPD, risk factors for suicide/overdose were identified that emphasize the subjective experience of illness over objective assessments of lung function.
Identifiants
pubmed: 36167120
pii: S0012-3692(22)03891-0
doi: 10.1016/j.chest.2022.09.022
pmc: PMC10083129
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
292-302Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL089856
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089897
Pays : United States
Investigateurs
James D Crapo
(JD)
Edwin K Silverman
(EK)
Barry J Make
(BJ)
Elizabeth A Regan
(EA)
Terri H Beaty
(TH)
Peter J Castaldi
(PJ)
Michael H Cho
(MH)
Dawn L DeMeo
(DL)
Adel El Boueiz
(A)
Marilyn G Foreman
(MG)
Auyon Ghosh
(A)
Lystra P Hayden
(LP)
Craig P Hersh
(CP)
Jacqueline Hetmanski
(J)
Brian D Hobbs
(BD)
John E Hokanson
(JE)
Wonji Kim
(W)
Nan Laird
(N)
Christoph Lange
(C)
Sharon M Lutz
(SM)
Merry-Lynn McDonald
(ML)
Dmitry Prokopenko
(D)
Matthew Moll
(M)
Jarrett Morrow
(J)
Dandi Qiao
(D)
Elizabeth A Regan
(EA)
Aabida Saferali
(A)
Phuwanat Sakornsakolpat
(P)
Edwin K Silverman
(EK)
Emily S Wan
(ES)
Jeong Yun
(J)
Juan Pablo Centeno
(JP)
Jean-Paul Charbonnier
(JP)
Harvey O Coxson
(HO)
Craig J Galban
(CJ)
MeiLan K Han
(MK)
Eric A Hoffman
(EA)
Stephen Humphries
(S)
Francine L Jacobson
(FL)
Philip F Judy
(PF)
Ella A Kazerooni
(EA)
Alex Kluiber
(A)
David A Lynch
(DA)
Pietro Nardelli
(P)
John D Newell
(JD)
Aleena Notary
(A)
Andrea Oh
(A)
Elizabeth A Regan
(EA)
James C Ross
(JC)
Raul San Jose Estepar
(R)
Joyce Schroeder
(J)
Jered Sieren
(J)
Berend C Stoel
(BC)
Juerg Tschirren
(J)
Edwin Van Beek
(E)
Bram van Ginneken
(B)
Eva van Rikxoort
(E)
Gonzalo Vegas Sanchez-Ferrero
(GV)
Lucas Veitel
(L)
George R Washko
(GR)
Carla G Wilson
(CG)
Robert Jensen
(R)
Matthew Strand
(M)
Jim Crooks
(J)
Katherine Pratte
(K)
Aastha Khatiwada
(A)
Carla G Wilson
(CG)
John E Hokanson
(JE)
Erin Austin
(E)
Gregory Kinney
(G)
Sharon M Lutz
(SM)
Kendra A Young
(KA)
Surya P Bhatt
(SP)
Jessica Bon
(J)
Alejandro A Diaz
(AA)
MeiLan K Han
(MK)
Barry Make
(B)
Susan Murray
(S)
Elizabeth Regan
(E)
Xavier Soler
(X)
Carla G Wilson
(CG)
Russell P Bowler
(RP)
Katerina Kechris
(K)
Farnoush Banaei-Kashani
(F)
Jeffrey L Curtis
(JL)
Perry G Pernicano
(PG)
Nicola Hanania
(N)
Mustafa Atik
(M)
Aladin Boriek
(A)
Kalpatha Guntupalli
(K)
Elizabeth Guy
(E)
Amit Parulekar
(A)
Dawn L DeMeo
(DL)
Craig Hersh
(C)
Francine L Jacobson
(FL)
George Washko
(G)
R Graham Barr
(RG)
John Austin
(J)
Belinda D'Souza
(B)
Byron Thomashow
(B)
Neil MacIntyre
(N)
H Page McAdams
(HP)
Lacey Washington
(L)
Charlene McEvoy
(C)
Joseph Tashjian
(J)
Robert Wise
(R)
Robert Brown
(R)
Nadia N Hansel
(NN)
Karen Horton
(K)
Allison Lambert
(A)
Nirupama Putcha
(N)
Richard Casaburi
(R)
Alessandra Adami
(A)
Matthew Budoff
(M)
Hans Fischer
(H)
Janos Porszasz
(J)
Harry Rossiter
(H)
William Stringer
(W)
Amir Sharafkhaneh
(A)
Charlie Lan
(C)
Christine Wendt
(C)
Brian Bell
(B)
Ken M Kunisaki
(KM)
Eric L Flenaugh
(EL)
Hirut Gebrekristos
(H)
Mario Ponce
(M)
Silanath Terpenning
(S)
Gloria Westney
(G)
Russell Bowler
(R)
David A Lynch
(DA)
Richard Rosiello
(R)
David Pace
(D)
Gerard Criner
(G)
David Ciccolella
(D)
Francis Cordova
(F)
Chandra Dass
(C)
Gilbert D'Alonzo
(G)
Parag Desai
(P)
Michael Jacobs
(M)
Steven Kelsen
(S)
Victor Kim
(V)
A James Mamary
(AJ)
Nathaniel Marchetti
(N)
Aditi Satti
(A)
Kartik Shenoy
(K)
Robert M Steiner
(RM)
Alex Swift
(A)
Irene Swift
(I)
Maria Elena Vega-Sanchez
(ME)
Mark Dransfield
(M)
William Bailey
(W)
Surya P Bhatt
(SP)
Anand Iyer
(A)
Hrudaya Nath
(H)
J Michael Wells
(JM)
Douglas Conrad
(D)
Xavier Soler
(X)
Andrew Yen
(A)
Alejandro P Comellas
(AP)
Karin F Hoth
(KF)
John Newell
(J)
Brad Thompson
(B)
MeiLan K Han
(MK)
Ella Kazerooni
(E)
Wassim Labaki
(W)
Craig Galban
(C)
Dharshan Vummidi
(D)
Joanne Billings
(J)
Abbie Begnaud
(A)
Tadashi Allen
(T)
Frank Sciurba
(F)
Jessica Bon
(J)
Divay Chandra
(D)
Joel Weissfeld
(J)
Antonio Anzueto
(A)
Sandra Adams
(S)
Diego Maselli-Caceres
(D)
Mario E Ruiz
(ME)
Harjinder Singh
(H)
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 American College of Chest Physicians. All rights reserved.
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