Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.
Bloodletting
Cadmium
Hemochromatosis
Lead
Mercury
Trace elements
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
20
06
2022
accepted:
12
09
2022
medline:
8
5
2023
pubmed:
29
9
2022
entrez:
28
9
2022
Statut:
ppublish
Résumé
Hemochromatosis is a hereditary disorder, most often associated with mutations of the HFE (High FErrum) gene. If left untreated, it can result in severe parenchymal iron accumulation. Bloodletting is the mainstay treatment. We have previously shown that treatment of hemochromatosis by repeated bloodlettings may induce changes in the serum levels of several trace elements. The aim of this work was to evaluate if whole blood concentrations of the environmental pollutants lead (Pb), mercury (Hg), and cadmium (Cd) could be affected by bloodlettings. We recruited 28 patients and 21 healthy individuals (control group). Whole blood and urine levels of Pb, Hg, and Cd were measured before the start and after the completion of treatment using inductively coupled plasma mass spectrometry, together with serum iron and liver function tests. Concentrations of blood Pb, but not Hg or Cd, were significantly increased after treatment. The increase in Pb was higher in C282Y homozygous patients than in the other patients, and it was positively correlated with the serum concentration of alkaline phosphatase. Bloodlettings in hemochromatosis result in an increase in the blood concentration of Pb. Augmented absorption due to iron loss or Pb mobilization from bone may contribute to the higher blood Pb level.
Identifiants
pubmed: 36168081
doi: 10.1007/s12011-022-03424-y
pii: 10.1007/s12011-022-03424-y
pmc: PMC10160177
doi:
Substances chimiques
Cadmium
00BH33GNGH
Lead
2P299V784P
Mercury
FXS1BY2PGL
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3193-3201Informations de copyright
© 2022. The Author(s).
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