Cell-type identity of the avian utricle.
CP: Cell biology
CP: Neuroscience
extrastriola
hair cell
hair cell production
inner ear
striola
supporting cell
turnover
vestibular apparatus
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
27 09 2022
27 09 2022
Historique:
received:
08
04
2021
revised:
18
07
2022
accepted:
08
09
2022
entrez:
28
9
2022
pubmed:
29
9
2022
medline:
1
10
2022
Statut:
ppublish
Résumé
The avian utricle, a vestibular organ of the inner ear, displays turnover of sensory hair cells throughout life. This is in sharp contrast to the mammalian utricle, which shows limited regenerative capacity. Here, we use single-cell RNA sequencing to identify distinct marker genes for the different sensory hair cell subtypes of the chicken utricle, which we validated in situ. We provide markers for spatially distinct supporting cell populations and identify two transitional cell populations of dedifferentiating supporting cells and developing hair cells. Trajectory reconstruction resulted in an inventory of gene expression dynamics of natural hair cell generation in the avian utricle.
Identifiants
pubmed: 36170825
pii: S2211-1247(22)01273-6
doi: 10.1016/j.celrep.2022.111432
pmc: PMC9588199
mid: NIHMS1839197
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111432Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC019619
Pays : United States
Organisme : NIH HHS
ID : S10 OD018220
Pays : United States
Organisme : NIH HHS
ID : S10 OD021763
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests S.H. is a paid consultant of Pipeline Therapeutics and Lineage Cell Therapeutics.
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