Direct evidence of nitric oxide production induced by lactoferrin and its enhancement by magnesium ions in cultured endothelial cells.
bovine aorta endothelial cell
cell culture
lactoferrin
magnesium
nitric oxide production
Journal
The Journal of veterinary medical science
ISSN: 1347-7439
Titre abrégé: J Vet Med Sci
Pays: Japan
ID NLM: 9105360
Informations de publication
Date de publication:
07 Nov 2022
07 Nov 2022
Historique:
pubmed:
29
9
2022
medline:
9
11
2022
entrez:
28
9
2022
Statut:
ppublish
Résumé
Bovine lactoferrin (BLF) reportedly lowers blood pressure and induces vasorelaxation, but its effect on nitric oxide (NO) production has not been established. Accordingly, we aimed to determine whether BLF induces NO production in bovine aortic endothelial cells, and the effects of extracellular free magnesium (Mg) ion concentrations on this NO production. BLF induced NO production time-dependently. NO production was markedly inhibited by the NO synthase inhibitor, N
Identifiants
pubmed: 36171111
doi: 10.1292/jvms.22-0368
pmc: PMC9705813
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Lactoferrin
EC 3.4.21.-
Magnesium
I38ZP9992A
Ions
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1499-1501Références
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