Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.
exercise physiology
metabolomics
pulmonary arterial hypertension
pulmonary hypertension
pulmonary vascular metabolism
pulmonary vascular reserve
right heart catheterization
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
06
2022
accepted:
23
08
2022
entrez:
29
9
2022
pubmed:
30
9
2022
medline:
30
9
2022
Statut:
epublish
Résumé
Pulmonary arterial hypertension is an incurable disease marked by dysregulated metabolism, both at the cellular level in the pulmonary vasculature, and at the whole-body level characterized by impaired exercise oxygen consumption. Though both altered pulmonary vascular metabolism and abnormal exercise physiology are key markers of disease severity and pulmonary arterial remodeling, their precise interactions are relatively unknown. Herein we review normal pulmonary vascular physiology and the current understanding of pulmonary vascular cell metabolism and cardiopulmonary response to exercise in Pulmonary arterial hypertension. We additionally introduce a newly developed international collaborative effort aimed at quantifying exercise-induced changes in pulmonary vascular metabolism, which will inform about underlying pathophysiology and clinical management. We support our investigative approach by presenting preliminary data and discuss potential future applications of our research platform.
Identifiants
pubmed: 36171971
doi: 10.3389/fphys.2022.963881
pii: 963881
pmc: PMC9510894
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
963881Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL152961
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135872
Pays : United States
Informations de copyright
Copyright © 2022 Lee, Menezes, Reisz, Ferreira, Graham and Oliveira.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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