New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors.
DPP8
DPP9
cancer
cell behavior
immune regulation
inflammation
organ fibrosis
pyroptosis
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
07
2022
accepted:
29
08
2022
entrez:
29
9
2022
pubmed:
30
9
2022
medline:
30
9
2022
Statut:
epublish
Résumé
Dipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate position. Because the localization of DPP8/9 is different from that of DPP4 and the substrates for DPP8/9 are not yet completely clear, their physiological and pathological roles are still being further explored. In this article, we will review the recent research advances focusing on the expression, regulation, and functions of DPP8/9 in physiology and pathology status. Emerging research results have shown that DPP8/9 is involved in various biological processes such as cell behavior, energy metabolism, and immune regulation, which plays an essential role in maintaining normal development and physiological functions of the body. DPP8/9 is also involved in pathological processes such as tumorigenesis, inflammation, and organ fibrosis. In recent years, related research on immune cell pyroptosis has made DPP8/9 a new potential target for the treatment of hematological diseases. In addition, DPP8/9 inhibitors also have great potential in the treatment of tumors and chronic kidney disease.
Identifiants
pubmed: 36172198
doi: 10.3389/fphar.2022.1002871
pii: 1002871
pmc: PMC9510841
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1002871Informations de copyright
Copyright © 2022 Cui, Tian, Wei, Wang, Wang and Fu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Med Chem. 2011 Aug 25;54(16):5737-46
pubmed: 21711053
J Cell Biol. 2020 Aug 3;219(8):
pubmed: 32479594
BMC Cancer. 2017 Sep 11;17(1):642
pubmed: 28893231
Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4
pubmed: 28392147
Immunol Lett. 2018 Jun;198:60-65
pubmed: 29709545
Elife. 2016 Sep 10;5:
pubmed: 27614019
Biochem J. 2006 Jun 1;396(2):391-9
pubmed: 16475979
Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5
pubmed: 29396289
Biol Chem. 2011 Mar;392(3):153-68
pubmed: 21194362
Nat Med. 2018 Aug;24(8):1151-1156
pubmed: 29967349
Immunity. 2021 Jul 13;54(7):1392-1404.e10
pubmed: 34019797
Biochim Biophys Acta. 2004 Jul 13;1679(1):18-28
pubmed: 15245913
Int J Cancer. 2014 Feb 1;134(3):530-41
pubmed: 23873303
Nat Commun. 2021 Jan 8;12(1):189
pubmed: 33420033
Cancers (Basel). 2021 Nov 01;13(21):
pubmed: 34771657
Int J Biochem Cell Biol. 2012 May;44(5):738-47
pubmed: 22306301
Front Physiol. 2018 Nov 14;9:1622
pubmed: 30487758
Nature. 2021 Apr;592(7856):778-783
pubmed: 33731932
J Neuroinflammation. 2012 Feb 28;9:44
pubmed: 22373413
Int J Cancer. 2017 Apr 1;140(7):1620-1632
pubmed: 27943262
Cell Death Dis. 2019 Aug 5;10(8):587
pubmed: 31383852
Sci Immunol. 2022 Sep 16;7(75):eabi4611
pubmed: 36112693
Clin Transl Gastroenterol. 2022 Jan 19;13(1):e00452
pubmed: 35060938
Biol Chem. 2011 Mar;392(3):189-98
pubmed: 21194356
Oncogene. 2018 Aug;37(32):4343-4357
pubmed: 29720723
Cell Mol Life Sci. 2014 Sep;71(18):3611-26
pubmed: 24562348
J Histochem Cytochem. 2008 Feb;56(2):147-55
pubmed: 17967935
J Biol Chem. 2012 Dec 28;287(53):44320-9
pubmed: 23152501
PLoS One. 2011;6(11):e27396
pubmed: 22087307
Trends Immunol. 2008 Jun;29(6):295-301
pubmed: 18456553
Cell Death Dis. 2020 Aug 14;11(8):628
pubmed: 32796818
J Biol Chem. 2011 Aug 5;286(31):27494-505
pubmed: 21680731
PLoS One. 2013;8(3):e58860
pubmed: 23554941
Virchows Arch. 2019 Feb;474(2):177-185
pubmed: 30467600
Nat Commun. 2021 Jan 8;12(1):188
pubmed: 33420028
Cancers (Basel). 2021 Apr 01;13(7):
pubmed: 33915844
PLoS One. 2021 Dec 7;16(12):e0259939
pubmed: 34874954
Cell Rep. 2016 Jun 7;15(10):2089-2096
pubmed: 27239038
Comput Struct Biotechnol J. 2021;19:6080-6089
pubmed: 34777716
Nat Genet. 2022 Apr;54(4):382-392
pubmed: 35241825
J Inflamm Res. 2022 Jan 04;15:17-32
pubmed: 35018108
Mol Immunol. 2020 Nov;127:193-202
pubmed: 32998073
Genome Med. 2021 May 17;13(1):83
pubmed: 34001247
J Immunother. 2013 Oct;36(8):400-11
pubmed: 23994886
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1437-E1445
pubmed: 29382749
Peptides. 2007 Feb;28(2):257-68
pubmed: 17223229
EMBO J. 2020 Oct 1;39(19):e105071
pubmed: 32840892
Nat Genet. 2013 Jun;45(6):613-20
pubmed: 23583980
Immunol Lett. 1995 Feb;45(1-2):47-51
pubmed: 7622187
Inflammation. 2016 Feb;39(1):413-424
pubmed: 26454447
J Cell Biochem. 2018 Aug;119(8):6743-6755
pubmed: 29693275
Onco Targets Ther. 2020 Mar 27;13:2599-2611
pubmed: 32273729
FEBS J. 2015 Oct;282(19):3737-57
pubmed: 26175140
J Leukoc Biol. 2007 May;81(5):1252-7
pubmed: 17287297
Chem Biol. 2011 Jul 29;18(7):846-56
pubmed: 21802006
J Histochem Cytochem. 2009 Nov;57(11):1025-40
pubmed: 19581630
Arch Biochem Biophys. 2009 May 15;485(2):120-7
pubmed: 19268648
Gene. 2002 Oct 16;299(1-2):185-93
pubmed: 12459266
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4154-8
pubmed: 18556199
World J Gastroenterol. 2013 May 21;19(19):2883-93
pubmed: 23704821
J Med Chem. 2007 Nov 15;50(23):5568-70
pubmed: 17958345
Biol Chem. 2004 Jun;385(6):557-9
pubmed: 15255190
Regul Pept. 2013 Sep 10;186:26-35
pubmed: 23850796
Biochim Biophys Acta. 2010 Apr;1804(4):781-8
pubmed: 20026260
Nature. 2021 Mar;591(7848):92-98
pubmed: 33307546
Biochem Pharmacol. 2009 Jul 15;78(2):203-10
pubmed: 19439267
Sci Rep. 2015 Aug 05;5:12348
pubmed: 26242871
Cancer Res. 2004 Aug 1;64(15):5471-80
pubmed: 15289357
J Clin Lab Anal. 2022 Jun;36(6):e24425
pubmed: 35441736
Cell Biochem Funct. 2017 Mar;35(2):124-137
pubmed: 28256001
FEBS J. 2006 Jun;273(11):2447-60
pubmed: 16704418
ACS Chem Biol. 2019 Nov 15;14(11):2424-2429
pubmed: 31525884
J Aerosol Med Pulm Drug Deliv. 2011 Apr;24(2):89-101
pubmed: 21410325
Int J Oncol. 2007 Oct;31(4):785-92
pubmed: 17786309
EMBO Rep. 2022 Aug 1;:e54136
pubmed: 35912982
Ann Surg Oncol. 2020 Oct;27(11):4337-4347
pubmed: 32734369
J Biol Chem. 2013 May 17;288(20):13936-13949
pubmed: 23519473
J Histochem Cytochem. 2009 Jun;57(6):531-41
pubmed: 19188489
Immunobiology. 2022 Mar;227(2):152184
pubmed: 35131543
ACS Pharmacol Transl Sci. 2021 Mar 19;4(2):1024-1025
pubmed: 33860221
Basic Res Cardiol. 2013 May;108(3):350
pubmed: 23608773
Int J Immunopharmacol. 1997 Jan;19(1):15-24
pubmed: 9226475
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4159-62
pubmed: 18556198
Sci Rep. 2019 Dec 2;9(1):18094
pubmed: 31792328
Cell Rep. 2020 Oct 13;33(2):108264
pubmed: 33053349
Pharmacol Res. 2021 Jul;169:105630
pubmed: 33932609
Nat Immun. 1994 Sep-Oct;13(5):270-9
pubmed: 7833626
Int J Oncol. 2010 Feb;36(2):351-8
pubmed: 20043068
J Biol Chem. 2018 Dec 7;293(49):18864-18878
pubmed: 30291141
Comput Struct Biotechnol J. 2022 May 30;20:2745-2758
pubmed: 35685372
J Allergy Clin Immunol. 2021 Jun;147(6):2134-2145.e20
pubmed: 33378691
Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91
pubmed: 15664838
Nat Chem Biol. 2017 Jan;13(1):46-53
pubmed: 27820798
Immunobiology. 2017 Feb;222(2):327-342
pubmed: 27682012
Diagnostics (Basel). 2021 Jul 02;11(7):
pubmed: 34359286
Clin Exp Immunol. 2005 Jan;139(1):17-24
pubmed: 15606609
Front Biosci (Landmark Ed). 2022 Jun 1;27(6):173
pubmed: 35748249
Cancer Biol Ther. 2010 Jul 15;10(2):180-9
pubmed: 20534982
Clin Chem Lab Med. 2009;47(3):268-74
pubmed: 19676138
Sci Rep. 2019 May 13;9(1):7292
pubmed: 31086209
J Gene Med. 2018 Dec;20(12):e3056
pubmed: 30225951
J Biol Chem. 2013 Nov 8;288(45):32787-32796
pubmed: 24072711
Pharmacol Ther. 2019 Jun;198:135-159
pubmed: 30822465
Cancer Genet. 2013 May;206(5):145-53
pubmed: 23726144
Nature. 2021 Apr;592(7856):773-777
pubmed: 33731929
J Biol Chem. 2009 Oct 2;284(40):27211-9
pubmed: 19667070
Mol Cancer Res. 2011 Jul;9(7):948-59
pubmed: 21622624
Dev Biol. 2017 Nov 15;431(2):297-308
pubmed: 28887018
Gastroenterology. 2007 May;132(6):2131-57
pubmed: 17498508
Am J Pathol. 2005 Feb;166(2):433-42
pubmed: 15681827
Int J Oncol. 2012 Sep;41(3):919-32
pubmed: 22736146
PLoS Pathog. 2012;8(4):e1002659
pubmed: 22536155
Exp Cell Res. 2016 Mar 1;342(1):72-82
pubmed: 26930324
Diabetes. 2005 Oct;54(10):2988-94
pubmed: 16186403
FEBS Lett. 2008 Mar 5;582(5):819-25
pubmed: 18275857
Leukemia. 2013 Jun;27(6):1236-44
pubmed: 23318959
Eur J Biochem. 2000 Oct;267(20):6140-50
pubmed: 11012666
Life Sci Alliance. 2019 Feb 4;2(1):
pubmed: 30718379
ChemMedChem. 2022 Aug 3;17(15):e202200097
pubmed: 35760756
Biol Chem. 2011 Mar;392(3):169-87
pubmed: 21194378
Biochim Biophys Acta. 2015 Feb;1853(2):470-80
pubmed: 25486458
Cardiovasc Diabetol. 2017 Jun 15;16(1):76
pubmed: 28619058
PLoS One. 2013 Nov 06;8(11):e78378
pubmed: 24223149
EMBO J. 2020 Oct 1;39(19):e103889
pubmed: 32815200
Immunopharmacology. 1998 Jul;40(1):21-6
pubmed: 9776475
Biochem J. 2003 Jul 1;373(Pt 1):179-89
pubmed: 12662155
Am J Respir Crit Care Med. 2019 Dec 1;200(11):1402-1413
pubmed: 31339356